OBJECTIVE: To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures. METHODS: The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age- and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index). RESULTS: MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31). CONCLUSIONS: Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.
OBJECTIVE: To examine the relationships among the variable number of tandem repeats in the monoamine oxidase-A linked polymorphic region allelic variation (MAOA-uVNTR) and the symptoms of depression and sleep quality. The monoamine oxidase-A (MAOA) gene, which plays a vital role in degradation of neurotransmitters such as serotonin, norepinephrine, and dopamine, contains a polymorphism in its promoter region (MAOA-uVNTR) that affects transcriptional efficiency. MAOA-uVNTR genotype has been associated with both psychological and physical measures. METHODS: The sample consisted of 74 males enrolled in a case/control study of caregivers for relatives with dementia. Age- and race-adjusted linear regression models were used to examine the association between low versus high MAOA-uVNTR activity alleles, symptoms of depression (Center for Epidemiological Studies of Depression), and sleep quality ratings (Pittsburgh Sleep Quality Index). RESULTS:MAOA-uVNTR alleles associated with less transcriptional activity were related to increased symptoms of depression (p < .04; Cohen's d = 0.52) and poorer sleep quality (p < .04; Cohen's d = 0.31). CONCLUSIONS: Individuals with less active MAOA-uVNTR alleles may be at increased risk for depressive symptoms and poor sleep.
Authors: J Deckert; M Catalano; Y V Syagailo; M Bosi; O Okladnova; D Di Bella; M M Nöthen; P Maffei; P Franke; J Fritze; W Maier; P Propping; H Beckmann; L Bellodi; K P Lesch Journal: Hum Mol Genet Date: 1999-04 Impact factor: 6.150
Authors: Indrani Halder; Karen A Matthews; Daniel J Buysse; Patrick J Strollo; Victoria Causer; Steven E Reis; Martica H Hall Journal: Sleep Date: 2015-08-01 Impact factor: 5.849
Authors: Sofia I Iqbal Kring; Beverly H Brummett; John Barefoot; Melanie E Garrett; Allison E Ashley-Koch; Stephen H Boyle; Ilene C Siegler; Thorkild I A Sørensen; Redford B Williams Journal: Psychosom Med Date: 2010-05-13 Impact factor: 4.312
Authors: Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Cynthia M Kuhn; Richard S Surwit; Melanie E Garrett; Ann Collins; Allison Ashley-Koch; Redford B Williams Journal: Biol Psychol Date: 2008-07-01 Impact factor: 3.251
Authors: Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Stephan Zuchner; Allison Ashley-Koch; Redford B Williams Journal: Med Sci Monit Date: 2008-02