OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations. METHODS: The association between rs769450, rs405509, rs439401, and metabolic traits were analyzed in a U.S. sample of 126 white caregivers of a relative with Alzheimer';s disease or other major dementia and 122 white controls. The associations were analyzed, using multivariate analysis of variance adjusted for age, sex, and medications. RESULTS: Significant multivariate interactions were found, using both additive (p = .009) and dominant (p = .047) models between rs439401 (C/T) and caregiver stress in relation to a profile of metabolic variables. Univariate analyses found the TT genotype to be associated with more adverse levels of waist circumference (interaction, p = .026), triglycerides (interaction, p = .001) and high-density lipoprotein cholesterol (interaction, p = .001) among caregivers but with a more favorable profile of these endophenotypes among controls. There were no significant associations or interactions involving the other two single nucleotide polymorphisms. CONCLUSION: The APOE rs439401 TT genotype is associated with an adverse metabolic profile among chronically stressed individuals compared with individuals not similarly stressed in whom a more favorable profile is expressed. Confirmation of these results in further research would indicate that the TT genotype can be used to identify persons at high risk for CVD when subjected to chronic stress.
OBJECTIVE: To examine the association between apolipoprotein E (APOE) gene variants and waist circumference, fasting plasma glucose, serum insulin, serum high-density lipoprotein cholesterol, and serum triglycerides, all metabolic traits known as cardiovascular disease (CVD) endophenotypes, in a population of stressed individuals and controls. Abdominal obesity, insulin resistance, elevated serum lipid concentration, and APOE polymorphisms have been associated with CVD risk. Current evidence supports the hypothesis that gene-environment interactions modulate serum lipid concentrations. METHODS: The association between rs769450, rs405509, rs439401, and metabolic traits were analyzed in a U.S. sample of 126 white caregivers of a relative with Alzheimer';s disease or other major dementia and 122 white controls. The associations were analyzed, using multivariate analysis of variance adjusted for age, sex, and medications. RESULTS: Significant multivariate interactions were found, using both additive (p = .009) and dominant (p = .047) models between rs439401 (C/T) and caregiver stress in relation to a profile of metabolic variables. Univariate analyses found the TT genotype to be associated with more adverse levels of waist circumference (interaction, p = .026), triglycerides (interaction, p = .001) and high-density lipoprotein cholesterol (interaction, p = .001) among caregivers but with a more favorable profile of these endophenotypes among controls. There were no significant associations or interactions involving the other two single nucleotide polymorphisms. CONCLUSION: The APOErs439401 TT genotype is associated with an adverse metabolic profile among chronically stressed individuals compared with individuals not similarly stressed in whom a more favorable profile is expressed. Confirmation of these results in further research would indicate that the TT genotype can be used to identify persons at high risk for CVD when subjected to chronic stress.
Authors: Beverly H Brummett; Michael A Babyak; Ilene C Siegler; Peter P Vitaliano; Edna L Ballard; Lisa P Gwyther; Redford B Williams Journal: Health Psychol Date: 2006-03 Impact factor: 4.267
Authors: R Jemaa; M Elasmi; C Naouali; M Feki; A Kallel; M Souissi; H Sanhaji; S Hadj Taïeb; O Souheil; N Kaabachi Journal: Clin Biochem Date: 2006-04-21 Impact factor: 3.281
Authors: Jari H Stengård; Sharon L R Kardia; Sara C Hamon; Ruth Frikke-Schmidt; Anne Tybjaerg-Hansen; Veikko Salomaa; Eric Boerwinkle; Charles F Sing Journal: J Lipid Res Date: 2005-11-29 Impact factor: 5.922
Authors: Roberto Elosua; Serkalem Demissie; L Adrienne Cupples; James B Meigs; Peter W F Wilson; Ernst J Schaefer; Dolores Corella; Jose M Ordovas Journal: Obes Res Date: 2003-12
Authors: Rong Jiang; Beverly H Brummett; Michael A Babyak; Ilene C Siegler; Redford B Williams Journal: J Psychiatr Res Date: 2012-11-08 Impact factor: 4.791
Authors: V Shahly; S Chatterji; M J Gruber; A Al-Hamzawi; J Alonso; L H Andrade; M C Angermeyer; R Bruffaerts; B Bunting; J M Caldas-de-Almeida; G de Girolamo; P de Jonge; S Florescu; O Gureje; J M Haro; H R Hinkov; C Hu; E G Karam; J-P Lépine; D Levinson; M E Medina-Mora; J Posada-Villa; N A Sampson; J K Trivedi; M C Viana; R C Kessler Journal: Psychol Med Date: 2012-08-09 Impact factor: 7.723
Authors: Rong Jiang; Beverly H Brummett; Elizabeth R Hauser; Michael A Babyak; Ilene C Siegler; Abanish Singh; Arne Astrup; Oluf Pedersen; Torben Hansen; Claus Holst; Thorkild I A Sørensen; Redford B Williams Journal: Biol Psychol Date: 2013-02-19 Impact factor: 3.251
Authors: Beverly H Brummett; Cynthia M Kuhn; Stephen H Boyle; Michael A Babyak; Ilene C Siegler; Redford B Williams Journal: Biol Psychol Date: 2011-10-01 Impact factor: 3.251
Authors: Abanish Singh; Michael A Babyak; Beverly H Brummett; Rong Jiang; Lana L Watkins; John C Barefoot; William E Kraus; Svati H Shah; Ilene C Siegler; Elizabeth R Hauser; Redford B Williams Journal: Genet Epidemiol Date: 2015-07-22 Impact factor: 2.135
Authors: Jennifer Schwartz; Matthew A Allison; Sonia Ancoli-Israel; Melbourne F Hovell; Ruth E Patterson; Loki Natarajan; Simon J Marshall; Igor Grant Journal: Arch Gerontol Geriatr Date: 2013-03-20 Impact factor: 3.250
Authors: Sofia I Iqbal Kring; John Barefoot; Beverly H Brummett; Stephen H Boyle; Ilene C Siegler; Søren Toubro; Torben Hansen; Arne Astrup; Oluf Pedersen; Redford B Williams; Thorkild I A Sørensen Journal: PLoS One Date: 2011-01-19 Impact factor: 3.240