BACKGROUND: This study investigated the effects of long-term cardiac resynchronization therapy (CRT) on the neurohormonal and cytokines levels in CHF patients and its correlation with changes in functional capacity (peak VO(2) and VO(2) AT) and left ventricular function (LVEF). METHODS: Brain natriuretic peptide (BNP), norepinephrine (NE), tumor necrosis factor alpha (TNF alpha), tumor necrosis factor alpha receptor 1 (TNF alpha R1) and interleukin 6 (IL-6) were collected from 22 patients of the PATH-CHF II study (LVEF< or =30%, NYHA II-IV and QRS> or =120 ms) at baseline and at the 12-month follow-up. Peak VO(2), VO(2) AT and LVEF were recorded. All patients were implanted with a CRT device using atrioventricular sequential left ventricular pacing. RESULTS: CRT led to a significant improvement of peak VO(2) (from 13+/-2.4 ml/kg/min to 14.8+/-2.8 ml/kg/min, p<0.05) and VO(2) AT (from 9+/-2 ml/kg/min to 10.1+/-1.9 ml/kg/min, p<0.05). LVEF increased significantly from 22.2+/-6.2% at baseline to 32+/-10.1% at 12-month follow-up (p<0.05). A significant reduction of BNP (from 332.9+/-295.2 to 193.4+/-253 pg/ml, p=0.049) and NE (410.6+/-306.0 to 274.4+/-174.3 ng/l, p=0.027) was also observed with CRT. CONCLUSION: Long-term CRT is associated with a significant decrease of BNP and NE levels and a significant improvement in functional capacity and LVEF.
BACKGROUND: This study investigated the effects of long-term cardiac resynchronization therapy (CRT) on the neurohormonal and cytokines levels in CHFpatients and its correlation with changes in functional capacity (peak VO(2) and VO(2) AT) and left ventricular function (LVEF). METHODS:Brain natriuretic peptide (BNP), norepinephrine (NE), tumor necrosis factor alpha (TNF alpha), tumor necrosis factor alpha receptor 1 (TNF alpha R1) and interleukin 6 (IL-6) were collected from 22 patients of the PATH-CHF II study (LVEF< or =30%, NYHA II-IV and QRS> or =120 ms) at baseline and at the 12-month follow-up. Peak VO(2), VO(2) AT and LVEF were recorded. All patients were implanted with a CRT device using atrioventricular sequential left ventricular pacing. RESULTS: CRT led to a significant improvement of peak VO(2) (from 13+/-2.4 ml/kg/min to 14.8+/-2.8 ml/kg/min, p<0.05) and VO(2) AT (from 9+/-2 ml/kg/min to 10.1+/-1.9 ml/kg/min, p<0.05). LVEF increased significantly from 22.2+/-6.2% at baseline to 32+/-10.1% at 12-month follow-up (p<0.05). A significant reduction of BNP (from 332.9+/-295.2 to 193.4+/-253 pg/ml, p=0.049) and NE (410.6+/-306.0 to 274.4+/-174.3 ng/l, p=0.027) was also observed with CRT. CONCLUSION: Long-term CRT is associated with a significant decrease of BNP and NE levels and a significant improvement in functional capacity and LVEF.
Authors: Alaa A Shalaby; William T Abraham; Gregg C Fonarow; Malcolm M Bersohn; John Gorcsan; Li-Yin Lee; Jasmina Halilovic; Samir Saba; Alan Maisel; Jagmeet P Singh; Ali Sonel; Alan Kadish Journal: Pacing Clin Electrophysiol Date: 2015-03-30 Impact factor: 1.976
Authors: Andrzej Rubaj; Piotr Ruciński; Krzysztof Oleszczak; Michał K Trojnar; Maciej Wójcik; Andrzej Wysokiński; Andrzej Kutarski Journal: Heart Vessels Date: 2012-12-16 Impact factor: 2.037
Authors: Yong-Mei Cha; Jae Oh; Chinami Miyazaki; David L Hayes; Robert F Rea; Win-Kuang Shen; Samuel J Asirvatham; Brad J Kemp; David O Hodge; Peng-Sheng Chen; Panithaya Chareonthaitawee Journal: J Cardiovasc Electrophysiol Date: 2008-05-09
Authors: Ross Arena; Jonathan Myers; Joshua Abella; Sherry Pinkstaff; Peter Brubaker; Brian Moore; Dalane Kitzman; Mary Ann Peberdy; Daniel Bensimhon; Paul Chase; Marco Guazzi Journal: Am Heart J Date: 2008-08-27 Impact factor: 4.749