Literature DB >> 17581804

Assessing biomarkers of oxidative stress: analysis of guanosine and oxidized guanosine nucleotide triphosphates by high performance liquid chromatography with electrochemical detection.

Celeste Bolin1, Fernando Cardozo-Pelaez.   

Abstract

Oxidation of the guanosine moiety in DNA has become a hallmark biomarker in assessing oxidative stress. The oxidation of guanosine in the nucleotide triphosphate pool has been overlooked due to the lack of a reliable methodology. This method describes a sample processing and high performance liquid chromatography with electrochemical detection protocol for the analysis of the cellular pool of guanosine triphosphates and oxidized guanosine triphosphates. Validation of this method is demonstrated along with evaluation of these analytes in control and oxidizing conditions in vitro and in HEK 293T cells. Oxidation of this triphosphate pool occurred independently of oxidation to DNA.

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Year:  2007        PMID： 17581804      PMCID： PMC2072907          DOI： 10.1016/j.jchromb.2007.05.034

Source DB:  PubMed          Journal:  J Chromatogr B Analyt Technol Biomed Life Sci        ISSN： 1570-0232            Impact factor:   3.205


  37 in total

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8.  Determination of the effects of mycophenolic acid on the nucleotide pool of human peripheral blood mononuclear cells in vitro by high-performance liquid chromatography.

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  8 in total

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Authors:  Giselle Cerchiaro; Celeste Bolin; Fernando Cardozo-Pelaez
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3.  Molecular and structural characterization of oxidized ribonucleotide insertion into DNA by human DNA polymerase β.

Authors:  Mallory R Smith; Khadijeh S Alnajjar; Nicole M Hoitsma; Joann B Sweasy; Bret D Freudenthal
Journal:  J Biol Chem       Date:  2019-12-31       Impact factor: 5.157

4.  Characterization of oxidized guanosine 5'-triphosphate as a viable inhibitor of soluble guanylyl cyclase.

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5.  Effect of mobile phase pH on the retention of nucleotides on different stationary phases for high-performance liquid chromatography.

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8.  Iron behaving badly: inappropriate iron chelation as a major contributor to the aetiology of vascular and other progressive inflammatory and degenerative diseases.

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  8 in total

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