Literature DB >> 17581644

Polyketides, proteins and genes in fungi: programmed nano-machines begin to reveal their secrets.

Russell J Cox1.   

Abstract

Fungi produce a wide variety of biologically active compounds. Among these, the polyketides form a large and structurally diverse group. These compounds are synthesised by highly programmed and very large iterative multifunctional proteins, the polyketide synthases, with nm dimensions. This review outlines the current state of knowledge regarding the links between gene sequence, protein architecture and biosynthetic programming for fungal polyketide synthases.

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Year:  2007        PMID： 17581644     DOI： 10.1039/b704420h

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  144 in total

1.  Identification of the viridicatumtoxin and griseofulvin gene clusters from Penicillium aethiopicum.

Authors:  Yit-Heng Chooi; Ralph Cacho; Yi Tang
Journal:  Chem Biol       Date:  2010-05-28

2.  Biosynthesis: An HR-PKS stereo surprise.

Authors:  Ikuro Abe
Journal:  Nat Chem Biol       Date:  2012-03-16       Impact factor: 15.040

Review 3.  New insights into the formation of fungal aromatic polyketides.

Authors:  Jason M Crawford; Craig A Townsend
Journal:  Nat Rev Microbiol       Date:  2010-12       Impact factor: 60.633

4.  Probing the selectivity and protein·protein interactions of a nonreducing fungal polyketide synthase using mechanism-based crosslinkers.

Authors:  Joel Bruegger; Robert W Haushalter; Bob Haushalter; Anna L Vagstad; Anna Vagstad; Gaurav Shakya; Nathan Mih; Craig A Townsend; Michael D Burkart; Shiou-Chuan Tsai
Journal:  Chem Biol       Date:  2013-08-29

Review 5.  Protein engineering towards natural product synthesis and diversification.

Authors:  Angelica O Zabala; Ralph A Cacho; Yi Tang
Journal:  J Ind Microbiol Biotechnol       Date:  2011-10-18       Impact factor: 3.346

6.  Molecular genetic analysis of the orsellinic acid/F9775 gene cluster of Aspergillus nidulans.

Authors:  James F Sanchez; Yi-Ming Chiang; Edyta Szewczyk; Ashley D Davidson; Manmeet Ahuja; C Elizabeth Oakley; Jin Woo Bok; Nancy Keller; Berl R Oakley; Clay C C Wang
Journal:  Mol Biosyst       Date:  2009-12-16

7.  Engineered biosynthesis of bacterial aromatic polyketides in Escherichia coli.

Authors:  Wenjun Zhang; Yanran Li; Yi Tang
Journal:  Proc Natl Acad Sci U S A       Date:  2008-12-15       Impact factor: 11.205

8.  Thioesterase-Catalyzed Aminoacylation and Thiolation of Polyketides in Fungi.

Authors:  Man-Cheng Tang; Curt R Fischer; Jason V Chari; Dan Tan; Sundari Suresh; Angela Chu; Molly Miranda; Justin Smith; Zhuan Zhang; Neil K Garg; Robert P St Onge; Yi Tang
Journal:  J Am Chem Soc       Date:  2019-05-10       Impact factor: 15.419

9.  Genes for the biosynthesis of the fungal polyketides hypothemycin from Hypomyces subiculosus and radicicol from Pochonia chlamydosporia.

Authors:  Christopher D Reeves; Zhihao Hu; Ralph Reid; James T Kealey
Journal:  Appl Environ Microbiol       Date:  2008-06-20       Impact factor: 4.792

10.  Complete reconstitution of a highly reducing iterative polyketide synthase.

Authors:  Suzanne M Ma; Jesse W-H Li; Jin W Choi; Hui Zhou; K K Michael Lee; Vijayalakshmi A Moorthie; Xinkai Xie; James T Kealey; Nancy A Da Silva; John C Vederas; Yi Tang
Journal:  Science       Date:  2009-10-23       Impact factor: 47.728
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