Literature DB >> 17581578

Chromatin dynamics and the preservation of genetic information.

Jessica A Downs1, Michel C Nussenzweig, André Nussenzweig.   

Abstract

The integrity of the genome is frequently challenged by double-strand breaks in the DNA. Defects in the cellular response to double-strand breaks are a major cause of cancer and other age-related pathologies; therefore, much effort has been directed at understanding the enzymatic mechanisms involved in recognizing, signalling and repairing double-strand breaks. Recent work indicates that chromatin - the fibres into which DNA is packaged with a proteinaceous structural polymer - has an important role in initiating, propagating and terminating this cellular response to DNA damage.

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Year:  2007        PMID： 17581578     DOI： 10.1038/nature05980

Source DB:  PubMed          Journal:  Nature        ISSN： 0028-0836            Impact factor:   49.962


  122 in total

1.  Requirement for the phospho-H2AX binding module of Crb2 in double-strand break targeting and checkpoint activation.

Authors:  Steven L Sanders; Ahmad R Arida; Funita P Phan
Journal:  Mol Cell Biol       Date:  2010-08-02       Impact factor: 4.272

Review 2.  Higher-order genome organization in human disease.

Authors:  Tom Misteli
Journal:  Cold Spring Harb Perspect Biol       Date:  2010-06-30       Impact factor: 10.005

3.  An essential role for a mammalian SWI/SNF chromatin-remodeling complex during male meiosis.

Authors:  Yuna Kim; Andrew M Fedoriw; Terry Magnuson
Journal:  Development       Date:  2012-02-08       Impact factor: 6.868

Review 4.  How chromatin-binding modules interpret histone modifications: lessons from professional pocket pickers.

Authors:  Sean D Taverna; Haitao Li; Alexander J Ruthenburg; C David Allis; Dinshaw J Patel
Journal:  Nat Struct Mol Biol       Date:  2007-11-05       Impact factor: 15.369

5.  UV sensitive mutations in histone H3 in Saccharomyces cerevisiae that alter specific K79 methylation states genetically act through distinct DNA repair pathways.

Authors:  Margery L Evans; Lindsey J Bostelman; Ashley M Albrecht; Andrew M Keller; Natasha T Strande; Jeffrey S Thompson
Journal:  Curr Genet       Date:  2008-03-08       Impact factor: 3.886

6.  Screening a genome-wide S. pombe deletion library identifies novel genes and pathways involved in genome stability maintenance.

Authors:  Gaurang P Deshpande; Jacqueline Hayles; Kwang-Lae Hoe; Dong-Uk Kim; Han-Oh Park; Edgar Hartsuiker
Journal:  DNA Repair (Amst)       Date:  2009-03-04

Review 7.  Kinases that control the cell cycle in response to DNA damage: Chk1, Chk2, and MK2.

Authors:  H Christian Reinhardt; Michael B Yaffe
Journal:  Curr Opin Cell Biol       Date:  2009-02-21       Impact factor: 8.382

8.  A chromatin-dependent role of the fragile X mental retardation protein FMRP in the DNA damage response.

Authors:  Roman Alpatov; Bluma J Lesch; Mika Nakamoto-Kinoshita; Andres Blanco; Shuzhen Chen; Alexandra Stützer; Karim J Armache; Matthew D Simon; Chao Xu; Muzaffar Ali; Jernej Murn; Sladjana Prisic; Tatiana G Kutateladze; Christopher R Vakoc; Jinrong Min; Robert E Kingston; Wolfgang Fischle; Stephen T Warren; David C Page; Yang Shi
Journal:  Cell       Date:  2014-05-08       Impact factor: 41.582

Review 9.  HMGNs, DNA repair and cancer.

Authors:  Gabi Gerlitz
Journal:  Biochim Biophys Acta       Date:  2009-12-08

10.  Role of Dot1 in the response to alkylating DNA damage in Saccharomyces cerevisiae: regulation of DNA damage tolerance by the error-prone polymerases Polzeta/Rev1.

Authors:  Francisco Conde; Pedro A San-Segundo
Journal:  Genetics       Date:  2008-06-18       Impact factor: 4.562
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