Literature DB >> 17578511

Long-lived dwarf mice: are bile acids a longevity signal?

David Gems1.   

Abstract

Pathways that control aging act via regulated biochemical processes, among which metabolism of xenobiotics (potentially harmful chemical agents encountered as environmental toxicants, for example, drugs, or produced internally) is one possible candidate. A new study of long-lived Ghrhr mutant mice reports that increased bile acid levels activate xenobiotic metabolism via the nuclear receptor, farnesoid X receptor. This increases resistance to xenobiotic stress, possibly contributing to longevity.

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Year:  2007        PMID： 17578511     DOI： 10.1111/j.1474-9726.2007.00309.x

Source DB:  PubMed          Journal:  Aging Cell        ISSN： 1474-9718            Impact factor:   9.304


  11 in total

1.  Chronic caloric restriction partially protects against age-related alteration in serum metabolome.

Authors:  Jennifer M De Guzman; Ginger Ku; Ryan Fahey; Yun-Hee Youm; Ignatius Kass; Donald K Ingram; Vishwa Deep Dixit; Indu Kheterpal
Journal:  Age (Dordr)       Date:  2012-06-04

2.  Interspecies Chemical Signals Released into the Environment May Create Xenohormetic, Hormetic and Cytostatic Selective Forces that Drive the Ecosystemic Evolution of Longevity Regulation Mechanisms.

Authors:  Michelle T Burstein; Adam Beach; Vincent R Richard; Olivia Koupaki; Alejandra Gomez-Perez; Alexander A Goldberg; Pavlo Kyryakov; Simon D Bourque; Anastasia Glebov; Vladimir I Titorenko
Journal:  Dose Response       Date:  2011-07-27       Impact factor: 2.658

3.  A photocleavable masked nuclear-receptor ligand enables temporal control of C. elegans development.

Authors:  Joshua C Judkins; Parag Mahanti; Jacob B Hoffman; Isaiah Yim; Adam Antebi; Frank C Schroeder
Journal:  Angew Chem Int Ed Engl       Date:  2014-01-22       Impact factor: 15.336

4.  Xenohormetic, hormetic and cytostatic selective forces driving longevity at the ecosystemic level.

Authors:  Alexander A Goldberg; Pavlo Kyryakov; Simon D Bourque; Vladimir I Titorenko
Journal:  Aging (Albany NY)       Date:  2010-08       Impact factor: 5.682

5.  Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes.

Authors:  Xinna Li; Andrzej Bartke; Darlene E Berryman; Kevin Funk; John J Kopchick; Edward O List; Liou Sun; Richard A Miller
Journal:  Am J Physiol Endocrinol Metab       Date:  2013-08-13       Impact factor: 4.310

6.  Chemical genetic screen identifies lithocholic acid as an anti-aging compound that extends yeast chronological life span in a TOR-independent manner, by modulating housekeeping longevity assurance processes.

Authors:  Alexander A Goldberg; Vincent R Richard; Pavlo Kyryakov; Simon D Bourque; Adam Beach; Michelle T Burstein; Anastasia Glebov; Olivia Koupaki; Tatiana Boukh-Viner; Christopher Gregg; Mylène Juneau; Ann M English; David Y Thomas; Vladimir I Titorenko
Journal:  Aging (Albany NY)       Date:  2010-07       Impact factor: 5.682

Review 7.  Mechanisms underlying the anti-aging and anti-tumor effects of lithocholic bile acid.

Authors:  Anthony Arlia-Ciommo; Amanda Piano; Veronika Svistkova; Sadaf Mohtashami; Vladimir I Titorenko
Journal:  Int J Mol Sci       Date:  2014-09-18       Impact factor: 5.923

8.  Empirical Validation of a Hypothesis of the Hormetic Selective Forces Driving the Evolution of Longevity Regulation Mechanisms.

Authors:  Alejandra Gomez-Perez; Pavlo Kyryakov; Michelle T Burstein; Nimara Asbah; Forough Noohi; Tania Iouk; Vladimir I Titorenko
Journal:  Front Genet       Date:  2016-12-06       Impact factor: 4.599

9.  The effects of graded levels of calorie restriction: XI. Evaluation of the main hypotheses underpinning the life extension effects of CR using the hepatic transcriptome.

Authors:  Davina Derous; Sharon E Mitchell; Lu Wang; Cara L Green; Yingchun Wang; Luonan Chen; Jing-Dong J Han; Daniel E L Promislow; David Lusseau; Alex Douglas; John R Speakman
Journal:  Aging (Albany NY)       Date:  2017-07-31       Impact factor: 5.682

10.  Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.

Authors:  Richard A Miller; David E Harrison; Clinton M Astle; Elizabeth Fernandez; Kevin Flurkey; Melissa Han; Martin A Javors; Xinna Li; Nancy L Nadon; James F Nelson; Scott Pletcher; Adam B Salmon; Zelton Dave Sharp; Sabrina Van Roekel; Lynn Winkleman; Randy Strong
Journal:  Aging Cell       Date:  2014-02-09       Impact factor: 9.304
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