Bacterial vaginosis and its implication in preterm labor and premature rupture of membranes. A review of the literature.

Preterm delivery continues to occur in 5% to 10% of all births, with a perinatal mortality rate between 50% and 80%. In recent years, the role of infection with lower genital tract organisms in precipitating preterm labor/delivery and premature rupture of membranes has come under considerable study. This article reviews the mechanisms by which infection may play a role in these problems, with a specific focus on bacterial vaginosis. Clinical management issues are addressed, including screening of prenatal patients, diagnostic criteria, and treatment possibilities.