Literature DB >> 17575072

Identification of a distant T-bet enhancer responsive to IL-12/Stat4 and IFNgamma/Stat1 signals.

Yu Yang1, Jordi C Ochando, Jonathan S Bromberg, Yaozhong Ding.   

Abstract

T-bet plays a critical role in controlling IFNgamma expression, Th1 polarization, and CD8 cytolytic development. Its regulation has been demonstrated to be mostly IFNgamma/Stat1 dependent while IL-12/Stat4 independent. Here we show that IL-12/Stat4 binds to a distant highly conserved STAT-responsive T-bet enhancer, and induces IFNgamma/Stat1-independent T-bet expression in CD8 T cells. Luciferase reporter assay showed that both Stat4 and Stat1 activate reporter gene expression from constructs containing a wild-type but not mutated T-bet enhancer. Studies in virus-infected mice demonstrated that the IL-12/Stat4/T-bet cascade operates in vivo and regulates IFNgamma in CD8 T cells. Together, we provide a novel mechanism for T-bet regulation, and suggest that IL-12/Stat4/T-bet play an important role in CD8 effector responses.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17575072      PMCID： PMC1988915          DOI： 10.1182/blood-2006-11-058271

Source DB:  PubMed          Journal:  Blood        ISSN： 0006-4971            Impact factor:   22.113


  39 in total

1.  T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells.

Authors:  A A Lighvani; D M Frucht; D Jankovic; H Yamane; J Aliberti; B D Hissong; B V Nguyen; M Gadina; A Sher; W E Paul; J J O'Shea
Journal:  Proc Natl Acad Sci U S A       Date:  2001-12-18       Impact factor: 11.205

2.  T-bet is a STAT1-induced regulator of IL-12R expression in naïve CD4+ T cells.

Authors:  Maryam Afkarian; John R Sedy; Jianfei Yang; Nils G Jacobson; Nezih Cereb; Soo Y Yang; Theresa L Murphy; Kenneth M Murphy
Journal:  Nat Immunol       Date:  2002-05-13       Impact factor: 25.606

3.  Differential IL-10R1 expression plays a critical role in IL-10-mediated immune regulation.

Authors:  Y Ding; L Qin; D Zamarin; S V Kotenko; S Pestka; K W Moore; J S Bromberg
Journal:  J Immunol       Date:  2001-12-15       Impact factor: 5.422

4.  Role of T-bet in commitment of TH1 cells before IL-12-dependent selection.

Authors:  A C Mullen; F A High; A S Hutchins; H W Lee; A V Villarino; D M Livingston; A L Kung; N Cereb; T P Yao; S Y Yang; S L Reiner
Journal:  Science       Date:  2001-06-08       Impact factor: 47.728

5.  Development of spontaneous airway changes consistent with human asthma in mice lacking T-bet.

Authors:  Susetta Finotto; Markus F Neurath; Jonathan N Glickman; Shixin Qin; Hans A Lehr; Francis H Y Green; Kate Ackerman; Kathleen Haley; Peter R Galle; Susanne J Szabo; Jeffrey M Drazen; George T De Sanctis; Laurie H Glimcher
Journal:  Science       Date:  2002-01-11       Impact factor: 47.728

6.  Distinct effects of T-bet in TH1 lineage commitment and IFN-gamma production in CD4 and CD8 T cells.

Authors:  Susanne J Szabo; Brandon M Sullivan; Claudia Stemmann; Abhay R Satoskar; Barry P Sleckman; Laurie H Glimcher
Journal:  Science       Date:  2002-01-11       Impact factor: 47.728

7.  Novel p19 protein engages IL-12p40 to form a cytokine, IL-23, with biological activities similar as well as distinct from IL-12.

Authors:  B Oppmann; R Lesley; B Blom; J C Timans; Y Xu; B Hunte; F Vega; N Yu; J Wang; K Singh; F Zonin; E Vaisberg; T Churakova; M Liu; D Gorman; J Wagner; S Zurawski; Y Liu; J S Abrams; K W Moore; D Rennick; R de Waal-Malefyt; C Hannum; J F Bazan; R A Kastelein
Journal:  Immunity       Date:  2000-11       Impact factor: 31.745

8.  Cloning and characterization of a new member of the T-box gene family.

Authors:  W X Zhang; S Y Yang
Journal:  Genomics       Date:  2000-11-15       Impact factor: 5.736

9.  Mechanism of transforming growth factor beta-induced inhibition of T helper type 1 differentiation.

Authors:  Leonid Gorelik; Stephanie Constant; Richard A Flavell
Journal:  J Exp Med       Date:  2002-06-03       Impact factor: 14.307

10.  The transcription factor T-bet regulates mucosal T cell activation in experimental colitis and Crohn's disease.

Authors:  M F Neurath; B Weigmann; S Finotto; J Glickman; E Nieuwenhuis; H Iijima; A Mizoguchi; E Mizoguchi; J Mudter; P R Galle; A Bhan; F Autschbach; B M Sullivan; S J Szabo; L H Glimcher; R S Blumberg
Journal:  J Exp Med       Date:  2002-05-06       Impact factor: 14.307
View more
  40 in total

Review 1.  Genetic and epigenetic networks controlling T helper 1 cell differentiation.

Authors:  Katarzyna Placek; Maryaline Coffre; Sylvie Maiella; Elisabetta Bianchi; Lars Rogge
Journal:  Immunology       Date:  2009-06       Impact factor: 7.397

Review 2.  Epigenetic control of T-helper-cell differentiation.

Authors:  Christopher B Wilson; Emily Rowell; Masayuki Sekimata
Journal:  Nat Rev Immunol       Date:  2009-02       Impact factor: 53.106

3.  Crystal structure of the DNA binding domain of the transcription factor T-bet suggests simultaneous recognition of distant genome sites.

Authors:  Ce Feng Liu; Gabriel S Brandt; Quyen Q Hoang; Natalia Naumova; Vanja Lazarevic; Eun Sook Hwang; Job Dekker; Laurie H Glimcher; Dagmar Ringe; Gregory A Petsko
Journal:  Proc Natl Acad Sci U S A       Date:  2016-10-10       Impact factor: 11.205

4.  Discrete roles of STAT4 and STAT6 transcription factors in tuning epigenetic modifications and transcription during T helper cell differentiation.

Authors:  Lai Wei; Golnaz Vahedi; Hong-Wei Sun; Wendy T Watford; Hiroaki Takatori; Haydee L Ramos; Hayato Takahashi; Jonathan Liang; Gustavo Gutierrez-Cruz; Chongzhi Zang; Weiqun Peng; John J O'Shea; Yuka Kanno
Journal:  Immunity       Date:  2010-06-25       Impact factor: 31.745

5.  iNKT cells require TSC1 for terminal maturation and effector lineage fate decisions.

Authors:  Jinhong Wu; Jialong Yang; Kai Yang; Hongxia Wang; Balachandra Gorentla; Jinwook Shin; Yurong Qiu; Loretta G Que; W Michael Foster; Zhenwei Xia; Hongbo Chi; Xiao-Ping Zhong
Journal:  J Clin Invest       Date:  2014-03-10       Impact factor: 14.808

Review 6.  T follicular helper cell programming by cytokine-mediated events.

Authors:  Kaitlin A Read; Michael D Powell; Kenneth J Oestreich
Journal:  Immunology       Date:  2016-08-16       Impact factor: 7.397

Review 7.  T Helper Cell Differentiation, Heterogeneity, and Plasticity.

Authors:  Jinfang Zhu
Journal:  Cold Spring Harb Perspect Biol       Date:  2018-10-01       Impact factor: 10.005

8.  PD-1/SHP-2 inhibits Tc1/Th1 phenotypic responses and the activation of T cells in the tumor microenvironment.

Authors:  Hyun-Bae Jie; Yu Lei; Jing Li; Neil Gildener-Leapman; Sumita Trivedi; Tony Green; Lawrence P Kane; Robert L Ferris
Journal:  Cancer Res       Date:  2014-12-05       Impact factor: 12.701

9.  Signal transducer and activator of transcription 4 is required for the transcription factor T-bet to promote T helper 1 cell-fate determination.

Authors:  Vivian T Thieu; Qing Yu; Hua-Chen Chang; Norman Yeh; Evelyn T Nguyen; Sarita Sehra; Mark H Kaplan
Journal:  Immunity       Date:  2008-11-14       Impact factor: 31.745

10.  Lung airway-surveilling CXCR3(hi) memory CD8(+) T cells are critical for protection against influenza A virus.

Authors:  Bram Slütter; Lecia L Pewe; Susan M Kaech; John T Harty
Journal:  Immunity       Date:  2013-11-14       Impact factor: 31.745
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.