| Literature DB >> 11397944 |
A C Mullen1, F A High, A S Hutchins, H W Lee, A V Villarino, D M Livingston, A L Kung, N Cereb, T P Yao, S Y Yang, S L Reiner.
Abstract
How cytokines control differentiation of helper T (TH) cells is controversial. We show that T-bet, without apparent assistance from interleukin 12 (IL-12)/STAT4, specifies TH1 effector fate by targeting chromatin remodeling to individual interferon-gamma (IFN-gamma) alleles and by inducing IL-12 receptor beta2 expression. Subsequently, it appears that IL-12/STAT4 serves two essential functions in the development of TH1 cells: as growth signal, inducing survival and cell division; and as trans-activator, prolonging IFN-gamma synthesis through a genetic interaction with the coactivator, CREB-binding protein. These results suggest that a cytokine does not simply induce TH fate choice but instead may act as an essential secondary stimulus that mediates selective survival of a lineage.Entities:
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Year: 2001 PMID： 11397944 DOI： 10.1126/science.1059835
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728