An environmental genomics perspective on the diversity and function of marine sponge-associated microbiota.

Numerous marine demosponges serve as habitats to phylogenetically complex microbial communities, with population densities exceeding those of seawater by several orders of magnitude. 16S rRNA gene-based studies have enabled a detailed phylogenetic description of the microorganisms associated with sponges, whereas environmental genomics analyses are beginning to reveal insights into their metabolic and physiological properties. Additionally, metagenomic approaches provide access to functional genes and gene clusters, thereby paving the way for the heterologous expression of novel bioactive substances from microbial symbionts of marine invertebrates.