Literature DB >> 17572864

Targeting the brain: rationalizing the novel methods of drug delivery to the central nervous system.

Shailendra Joshi1, Eugene Ornstein, Jeffrey N Bruce.   

Abstract

Drug delivery to the brain has remained one of the most vexing problems in translational neuroscience research. This review rationalizes the strategies to target drugs to the brain. Factors such as the speed of intervention, the scale of intervention, the state of BBB, and the permissible risks, will all be critical in deciding how best to deliver drugs to a target site in the brain for a specific clinical situation.

Mesh：

Year:  2007        PMID： 17572864     DOI： 10.1007/s12028-007-0034-8

Source DB:  PubMed          Journal:  Neurocrit Care        ISSN： 1541-6933            Impact factor:   3.210


  82 in total

Review 1.  Pharmaceutical strategies utilizing recombinant human serum albumin.

Authors:  Victor Tuan Giam Chuang; Ulrich Kragh-Hansen; Masaki Otagiri
Journal:  Pharm Res       Date:  2002-05       Impact factor: 4.200

2.  Permeability of bovine brain microvessel endothelial cells in vitro: barrier tightening by a factor released from astroglioma cells.

Authors:  T J Raub; S L Kuentzel; G A Sawada
Journal:  Exp Cell Res       Date:  1992-04       Impact factor: 3.905

3.  Brain uptake of benzodiazepines: effects of lipophilicity and plasma protein binding.

Authors:  D R Jones; S D Hall; E K Jackson; R A Branch; G R Wilkinson
Journal:  J Pharmacol Exp Ther       Date:  1988-06       Impact factor: 4.030

4.  Structural changes in the rat brain after carotid infusions of hyperosmolar solutions. An electron microscopic study.

Authors:  T S Salahuddin; B B Johansson; H Kalimo; Y Olsson
Journal:  Acta Neuropathol       Date:  1988       Impact factor: 17.088

5.  The mechanism of reversible osmotic opening of the blood-brain barrier: role of intracellular calcium ion in capillary endothelial cells.

Authors:  T Nagashima; K Ikeda; S Wu; T Kondo; M Yamaguchi; N Tamaki
Journal:  Acta Neurochir Suppl       Date:  1997

Review 6.  Drug transfer across the blood-brain barrier and improvement of brain delivery.

Authors:  P Jolliet-Riant; J P Tillement
Journal:  Fundam Clin Pharmacol       Date:  1999       Impact factor: 2.748

7.  The feasibility of intracarotid adenosine for the manipulation of human cerebrovascular resistance.

Authors:  S Joshi; W L Young; J Pile-Spellman; D H Duong; M C Vang; L Hacein-Bey; H T Lee; N Ostapkovich
Journal:  Anesth Analg       Date:  1998-12       Impact factor: 5.108

8.  Hemorrhagic encephalitis produced by selective non-occlusive intracarotid BCNU injection in dogs.

Authors:  M F Omojola; A J Fox; R N Auer; F V Viñuela
Journal:  J Neurosurg       Date:  1982-12       Impact factor: 5.115

Review 9.  Why do all drugs work in animals but none in stroke patients? 1. Drugs promoting cerebral blood flow.

Authors:  G J Del Zoppo
Journal:  J Intern Med       Date:  1995-01       Impact factor: 8.989

10.  Brain targeting of anti-HIV nucleosides: synthesis and in vitro and in vivo studies of dihydropyridine derivatives of 3'-azido-2',3'-dideoxyuridine and 3'-azido-3'-deoxythymidine.

Authors:  C K Chu; V S Bhadti; K J Doshi; J T Etse; J M Gallo; F D Boudinot; R F Schinazi
Journal:  J Med Chem       Date:  1990-08       Impact factor: 7.446
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  5 in total

Review 1.  PDE4 as a target for cognition enhancement.

Authors:  Wito Richter; Frank S Menniti; Han-Ting Zhang; Marco Conti
Journal:  Expert Opin Ther Targets       Date:  2013-07-25       Impact factor: 6.902

Review 2.  Pediatric diffuse intrinsic pontine glioma: can optimism replace pessimism?

Authors:  Darren Hargrave
Journal:  CNS Oncol       Date:  2012-11

3.  Astrocyte- and endothelial-targeted CCL2 conditional knockout mice: critical tools for studying the pathogenesis of neuroinflammation.

Authors:  Shujun Ge; Nivetha Murugesan; Joel S Pachter
Journal:  J Mol Neurosci       Date:  2009-04-02       Impact factor: 3.444

Review 4.  Intracarotid delivery of drugs: the potential and the pitfalls.

Authors:  Shailendra Joshi; Phillip M Meyers; Eugene Ornstein
Journal:  Anesthesiology       Date:  2008-09       Impact factor: 7.892

5.  Cationic surface charge enhances early regional deposition of liposomes after intracarotid injection.

Authors:  Shailendra Joshi; Rajinder Singh-Moon; Mei Wang; Durba B Chaudhuri; Jason A Ellis; Jeffrey N Bruce; Irving J Bigio; Robert M Straubinger
Journal:  J Neurooncol       Date:  2014-09-07       Impact factor: 4.130
  5 in total

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