Literature DB >> 17572089

Synthesis of benzothiazole semicarbazones as novel anticonvulsants--the role of hydrophobic domain.

Nadeem Siddiqui1, Arpana Rana, Suroor A Khan, Mashooq A Bhat, Syed E Haque.   

Abstract

A series of 1,3-benzothiazol-2-yl semicarbazones (1-15) were prepared in satisfactory yield and evaluated for their anticonvulsant, neurotoxicity and other toxicity studies. All the synthesized compounds were in good agreement with elemental and spectral data. Majority of the compounds were active in MES screen. Selected compounds were checked for their lipophilic character.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17572089     DOI： 10.1016/j.bmcl.2007.05.048

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  9 in total

1.  Diversity-oriented synthesis of benzimidazole, benzoxazole, benzothiazole and quinazolin-4(3H)-one libraries via potassium persulfate-CuSO4-mediated oxidative coupling reactions of aldehydes in aqueous micelles.

Authors:  Atul Kumar; Ram Awatar Maurya; Deepti Saxena
Journal:  Mol Divers       Date:  2009-07-04       Impact factor: 2.943

2.  Anatomical structure of Camellia oleifera shell.

Authors:  Jinbo Hu; Yang Shi; Yuan Liu; Shanshan Chang
Journal:  Protoplasma       Date:  2018-06-04       Impact factor: 3.356

3.  Synthesis and evaluation of substituted diphenyl-1,3,4-oxadiazole derivatives for central nervous system depressant activity.

Authors:  Poonam Singh; Pramod Kumar Sharma; Jitendra Kumar Sharma; Anshu Upadhyay; Nitin Kumar
Journal:  Org Med Chem Lett       Date:  2012-03-01

4.  Synthesis, In Vitro α-Glucosidase Inhibitory Activity and Molecular Docking Studies of Novel Benzothiazole-Triazole Derivatives.

Authors:  Zipeng Gong; Yaping Peng; Jie Qiu; Anbai Cao; Guangcheng Wang; Zhiyun Peng
Journal:  Molecules       Date:  2017-09-15       Impact factor: 4.411

5.  Synthesis and anticonvulsant properties of 1-(amino-N-arylmethanethio)-3-(1-substituted benzyl-2, 3-dioxoindolin-5-yl) urea derivatives.

Authors:  Nadeem Siddiqui; M Shamsher Alam; James P Stables
Journal:  Eur J Med Chem       Date:  2011-03-10       Impact factor: 6.514

Review 6.  Pharmaceutical and medicinal significance of sulfur (SVI)-Containing motifs for drug discovery: A critical review.

Authors:  Chuang Zhao; K P Rakesh; L Ravidar; Wan-Yin Fang; Hua-Li Qin
Journal:  Eur J Med Chem       Date:  2018-11-22       Impact factor: 6.514

7.  Synthesis of benzo[d]thiazole-hydrazone analogues: molecular docking and SAR studies of potential H+/K+ ATPase inhibitors and anti-inflammatory agents.

Authors:  Shi-Meng Wang; Gao-Feng Zha; K P Rakesh; N Darshini; T Shubhavathi; H K Vivek; N Mallesha; Hua-Li Qin
Journal:  Medchemcomm       Date:  2017-04-26       Impact factor: 3.597

Review 8.  Benzothiazole derivatives as anticancer agents.

Authors:  Ali Irfan; Fozia Batool; Syeda Andleeb Zahra Naqvi; Amjad Islam; Sameh M Osman; Alessio Nocentini; Siham A Alissa; Claudiu T Supuran
Journal:  J Enzyme Inhib Med Chem       Date:  2020-12       Impact factor: 5.051

9.  Design, Synthesis and Biological Evaluation of Benzo[D]Thiazole with Dimethylpyrazol Derivatives.

Authors:  Dachuan Liu; Xiu Cheng; Ying Wang
Journal:  Asian Pac J Cancer Prev       Date:  2019-11-01
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.