Literature DB >> 17571184

[3 + 2] Cycloaddition of acetylenes with azides to give 1,4-disubstituted 1,2,3-triazoles in a modular flow reactor.

Christopher D Smith1, Ian R Baxendale, Steve Lanners, John J Hayward, Stephen C Smith, Steven V Ley.   

Abstract

The cycloaddition of acetylenes with azides to give the corresponding 1,4-disubstituted 1,2,3-triazoles is reported using immobilised reagents and scavengers in pre-packed glass tubes in a modular flow reactor.

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Year:  2007        PMID： 17571184     DOI： 10.1039/b702995k

Source DB:  PubMed          Journal:  Org Biomol Chem        ISSN： 1477-0520            Impact factor:   3.876


  10 in total

1.  The flow synthesis of heterocycles for natural product and medicinal chemistry applications.

Authors:  Marcus Baumann; Ian R Baxendale; Steven V Ley
Journal:  Mol Divers       Date:  2010-10-20       Impact factor: 2.943

2.  In-Line Purification: A Key Component to Facilitate Drug Synthesis and Process Development in Medicinal Chemistry.

Authors:  Nopphon Weeranoppanant; Andrea Adamo
Journal:  ACS Med Chem Lett       Date:  2019-12-12       Impact factor: 4.345

3.  In situ generation and intramolecular Schmidt reaction of keto azides in a microwave-assisted flow format.

Authors:  Thomas O Painter; Paul D Thornton; Mario Orestano; Conrad Santini; Michael G Organ; Jeffrey Aubé
Journal:  Chemistry       Date:  2011-07-27       Impact factor: 5.236

4.  Ultrasound-promoted copper-catalyzed azide-alkyne cycloaddition.

Authors:  Giancarlo Cravotto; Valery V Fokin; Davide Garella; Arianna Binello; Luisa Boffa; Alessandro Barge
Journal:  J Comb Chem       Date:  2010 Jan-Feb

5.  Continuous flow based catch and release protocol for the synthesis of alpha-ketoesters.

Authors:  Alessandro Palmieri; Steven V Ley; Anastasios Polyzos; Mark Ladlow; Ian R Baxendale
Journal:  Beilstein J Org Chem       Date:  2009-05-20       Impact factor: 2.883

6.  Continuous flow enantioselective arylation of aldehydes with ArZnEt using triarylboroxins as the ultimate source of aryl groups.

Authors:  Julien Rolland; Xacobe C Cambeiro; Carles Rodríguez-Escrich; Miquel A Pericàs
Journal:  Beilstein J Org Chem       Date:  2009-10-15       Impact factor: 2.883

7.  Continuous-flow enantioselective α-aminoxylation of aldehydes catalyzed by a polystyrene-immobilized hydroxyproline.

Authors:  Xacobe C Cambeiro; Rafael Martín-Rapún; Pedro O Miranda; Sonia Sayalero; Esther Alza; Patricia Llanes; Miquel A Pericàs
Journal:  Beilstein J Org Chem       Date:  2011-10-31       Impact factor: 2.883

8.  Efficient continuous-flow synthesis of novel 1,2,3-triazole-substituted β-aminocyclohexanecarboxylic acid derivatives with gram-scale production.

Authors:  Sándor B Otvös; Adám Georgiádes; István M Mándity; Lóránd Kiss; Ferenc Fülöp
Journal:  Beilstein J Org Chem       Date:  2013-07-29       Impact factor: 2.883

9.  QuadraPure-supported palladium nanocatalysts for microwave-promoted Suzuki cross-coupling reaction under aerobic condition.

Authors:  Kin Hong Liew; Poh Lee Loh; Joon Ching Juan; Mohd Ambar Yarmo; Rahimi M Yusop
Journal:  ScientificWorldJournal       Date:  2014-06-25

10.  "Flash" solvent-free synthesis of triazoles using a supported catalyst.

Authors:  Ibtissem Jlalia; Faouzi Meganem; Jean Herscovici; Christian Girard
Journal:  Molecules       Date:  2009-01-22       Impact factor: 4.411
  10 in total

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