BACKGROUND: Several lipid ratios may be predictors of coronary artery disease risk. We assessed the efficacy of Monascus purpureus Went rice (red yeast rice) on lowering lipid ratios. METHOD AND RESULTS: We evaluated 79 hypercholesterolemic patients (aged 23-65 years) who received a twice-daily dose of either red yeast rice or a placebo at 600 mg for 8 weeks. The 8-week treatment with red yeast rice showed significantly greater reduction than the placebo treatment in low-density lipoprotein cholesterol levels, total cholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and apolipoprotein B/apolipoprotein A-I ratios. CONCLUSIONS:Red yeast rice can reduce lipid ratios in hypercholesterolemic patients.
RCT Entities:
BACKGROUND: Several lipid ratios may be predictors of coronary artery disease risk. We assessed the efficacy of Monascus purpureus Went rice (red yeastrice) on lowering lipid ratios. METHOD AND RESULTS: We evaluated 79 hypercholesterolemicpatients (aged 23-65 years) who received a twice-daily dose of either red yeastrice or a placebo at 600 mg for 8 weeks. The 8-week treatment with red yeastrice showed significantly greater reduction than the placebo treatment in low-density lipoprotein cholesterol levels, total cholesterol/high-density lipoprotein cholesterol, low-density lipoprotein cholesterol/high-density lipoprotein cholesterol and apolipoprotein B/apolipoprotein A-I ratios. CONCLUSIONS: Red yeastrice can reduce lipid ratios in hypercholesterolemicpatients.
Authors: Donald I Abrams; Paul Couey; Starley B Shade; Mary Ellen Kelly; Nnemdi Kamanu-Elias; Paul Stamets Journal: BMC Complement Altern Med Date: 2011-08-10 Impact factor: 3.659