Literature DB >> 17567059

Post-translational modifications in the rat lumbar spinal cord in experimental autoimmune encephalomyelitis.

Jennifer E Grant1, Jun Hu, Tong Liu, Mohit R Jain, Stella Elkabes, Hong Li.   

Abstract

Changes in protein methylation, citrullination, and phosphorylation during experimental autoimmune encephalomyelitis, a rodent model of multiple sclerosis, were evaluated using isobaric tags for relative and absolute quantification analysis of peptides produced from normal and diseased rat lumbar spinal cords. We observed alterations in the post-translational modification of key proteins regulating signal transduction and axonal integrity. Dephosphorylation of discrete serine residues within the neurofilament heavy subunit C-terminus was observed. We report for the first time elevated citrullination of Arg27 in glial fibrillary acidic protein, which may contribute to the pathophysiology of astrocytes.

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Year:  2007        PMID： 17567059      PMCID： PMC2435290          DOI： 10.1021/pr070013c

Source DB:  PubMed          Journal:  J Proteome Res        ISSN： 1535-3893            Impact factor:   4.466


  48 in total

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