| Literature DB >> 17560674 |
Mark W Dewhirst1, Yiting Cao, Chuan Yuan Li, Benjamin Moeller.
Abstract
The objective of this review is to examine the role that HIF-1 plays in the initiation of angiogenesis and in radiotherapy response. Although these two phenomena may at first seem unrelated, there are parallelisms to be drawn associated with the importance of reactive oxygen species in controlling the transcriptional activity of HIF-1, independently of its main driving force, hypoxia. Knowledge of the mechanisms underlying the control of HIF-1 leads to rationale for its inhibition in a range of clinical scenarios.Entities:
Mesh：
Substances：
Year: 2007 PMID： 17560674 PMCID： PMC2694841 DOI： 10.1016/j.radonc.2007.05.016
Source DB: PubMed Journal: Radiother Oncol ISSN： 0167-8140 Impact factor: 6.280