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Literature DB >> 17557928

The IRF5 polymorphism in type 1 diabetes.

Hui-Qi Qu, Luc Marchand, Rosemary Grabs, Constantin Polychronakos.

Abstract

The interferon regulatory factor 5 gene (IRF5) has been shown to play a crucial role in harmful immune responses by induction of proinflammatory cytokines. Functional genetic variants associated with increased IRF5 expression of specific isoforms are associated with systemic lupus erythematosus (SLE) and it is possible that they may also predispose to other autoimmune disorders. We tested the association of two IRF5 SNPs, correlated with IRF5 expression and SLE risk, in 947 nuclear family trios type 1 diabetes (T1D) using the transmission disequilibrium test. Our results suggest that the functional IRF5 variations do not confer an obvious risk for T1D.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17557928 PMCID： PMC2597969 DOI： 10.1136/jmg.2007.050971

Source DB: PubMed Journal: J Med Genet ISSN： 0022-2593 Impact factor: 6.318

14 in total

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Journal: Bioinformatics Date: 2004-08-05 Impact factor: 6.937

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Journal: J Biol Chem Date: 2001-04-12 Impact factor: 5.157

3. A common haplotype of interferon regulatory factor 5 (IRF5) regulates splicing and expression and is associated with increased risk of systemic lupus erythematosus.

Authors: Robert R Graham; Sergey V Kozyrev; Emily C Baechler; M V Prasad Linga Reddy; Robert M Plenge; Jason W Bauer; Ward A Ortmann; Thearith Koeuth; Ma Francisca González Escribano; Bernardo Pons-Estel; Michelle Petri; Mark Daly; Peter K Gregersen; Javier Martín; David Altshuler; Timothy W Behrens; Marta E Alarcón-Riquelme
Journal: Nat Genet Date: 2006-04-16 Impact factor: 38.330

4. Polymorphisms in the tyrosine kinase 2 and interferon regulatory factor 5 genes are associated with systemic lupus erythematosus.

Authors: Snaevar Sigurdsson; Gunnel Nordmark; Harald H H Göring; Katarina Lindroos; Ann-Christin Wiman; Gunnar Sturfelt; Andreas Jönsen; Solbritt Rantapää-Dahlqvist; Bozena Möller; Juha Kere; Sari Koskenmies; Elisabeth Widén; Maija-Leena Eloranta; Heikki Julkunen; Helga Kristjansdottir; Kristjan Steinsson; Gunnar Alm; Lars Rönnblom; Ann-Christine Syvänen
Journal: Am J Hum Genet Date: 2005-01-18 Impact factor: 11.025

5. Integral role of IRF-5 in the gene induction programme activated by Toll-like receptors.

Authors: Akinori Takaoka; Hideyuki Yanai; Seiji Kondo; Gordon Duncan; Hideo Negishi; Tatsuaki Mizutani; Shin-Ichi Kano; Kenya Honda; Yusuke Ohba; Tak W Mak; Tadatsugu Taniguchi
Journal: Nature Date: 2005-01-23 Impact factor: 49.962

Review 6. A choice of death--the signal-transduction of immune-mediated beta-cell apoptosis.

Authors: D L Eizirik; T Mandrup-Poulsen
Journal: Diabetologia Date: 2001-12 Impact factor: 10.122

Review 7. Delineating the genetic basis of systemic lupus erythematosus.

Authors: E K Wakeland; K Liu; R R Graham; T W Behrens
Journal: Immunity Date: 2001-09 Impact factor: 31.745

Review 8. The Type 1 Diabetes Genetics Consortium.

Authors: Stephen S Rich; Patrick Concannon; Henry Erlich; Cecile Julier; Grant Morahan; Jorn Nerup; Flemming Pociot; John A Todd
Journal: Ann N Y Acad Sci Date: 2006-10 Impact factor: 5.691

9. Association of a common interferon regulatory factor 5 (IRF5) variant with increased risk of systemic lupus erythematosus (SLE).

Authors: F Y K Demirci; S Manzi; R Ramsey-Goldman; R L Minster; M Kenney; P S Shaw; C M Dunlop-Thomas; A H Kao; E Rhew; F Bontempo; C Kammerer; M I Kamboh
Journal: Ann Hum Genet Date: 2006-12-12 Impact factor: 1.670