H-Q Qu1, L Marchand, R Grabs, C Polychronakos. 1. Endocrine Genetics Lab, The McGill University Health Center (Montreal Children's Hospital), 2300 Tupper, Montreal, QC, Canada, H3H 1P3.
Abstract
AIMS/HYPOTHESIS: We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS: We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and rs984971589, in 589 type 1 diabetes nuclear family trios (1,767 individuals). RESULTS: This study independently replicated the reported genetic association using a family-based approach. CONCLUSIONS/ INTERPRETATION: The reported type 1 diabetes association is from a linkage disequilibrium region including three candidate genes, i.e. FAP, IFIH1 and GCA. Further variant discovery and fine mapping could help clarify a novel type 1 diabetes mechanism.
AIMS/HYPOTHESIS: We set out to validate a recently reported type 1 diabetes association from the IFIH1 gene variation in an independent cohort from a population of mixed European descent. METHODS: We genotyped five single-nucleotide polymorphisms in the IFIH1 locus, i.e. rs2111485, rs1990760, rs3747517, rs17783344 and rs984971589, in 589 type 1 diabetes nuclear family trios (1,767 individuals). RESULTS: This study independently replicated the reported genetic association using a family-based approach. CONCLUSIONS/ INTERPRETATION: The reported type 1 diabetes association is from a linkage disequilibrium region including three candidate genes, i.e. FAP, IFIH1 and GCA. Further variant discovery and fine mapping could help clarify a novel type 1 diabetes mechanism.
Authors: Deborah J Smyth; Jason D Cooper; Rebecca Bailey; Sarah Field; Oliver Burren; Luc J Smink; Cristian Guja; Constantin Ionescu-Tirgoviste; Barry Widmer; David B Dunger; David A Savage; Neil M Walker; David G Clayton; John A Todd Journal: Nat Genet Date: 2006-05-14 Impact factor: 38.330
Authors: Martin Fassnacht; Jaewoo Lee; Caterina Milazzo; David Boczkowski; Zhen Su; Smita Nair; Eli Gilboa Journal: Clin Cancer Res Date: 2005-08-01 Impact factor: 12.531
Authors: Siyang Liu; Hongjie Wang; Yulan Jin; Robert Podolsky; M V Prasad Linga Reddy; Jennifer Pedersen; Bruce Bode; John Reed; Dennis Steed; Steve Anderson; Ping Yang; Andy Muir; Leigh Steed; Diane Hopkins; Yihua Huang; Sharad Purohit; Cong-Yi Wang; Andrea K Steck; Annalisa Montemari; George Eisenbarth; Marian Rewers; Jin-Xiong She Journal: Hum Mol Genet Date: 2008-10-16 Impact factor: 6.150
Authors: A Jermendy; I Szatmári; A P Laine; K Lukács; K H Horváth; A Körner; L Madácsy; R Veijola; O Simell; M Knip; J Ilonen; R Hermann Journal: Diabetologia Date: 2009-10-20 Impact factor: 10.122
Authors: Martin Jaeger; Robin van der Lee; Shih-Chin Cheng; Melissa D Johnson; Vinod Kumar; Aylwin Ng; Theo S Plantinga; Sanne P Smeekens; Marije Oosting; Xinhui Wang; Winfried Barchet; Kate Fitzgerald; Leo A B Joosten; John R Perfect; Cisca Wijmenga; Frank L van de Veerdonk; Martijn A Huynen; Ramnik J Xavier; Bart-Jan Kullberg; Mihai G Netea Journal: Eur J Clin Microbiol Infect Dis Date: 2015-01-13 Impact factor: 3.267
Authors: Benjamin M Looney; Chang-Qing Xia; Patrick Concannon; David A Ostrov; Michael J Clare-Salzler Journal: Curr Diab Rep Date: 2015-11 Impact factor: 4.810
Authors: Elisabet Witsø; German Tapia; Ondrej Cinek; Flemming Michael Pociot; Lars C Stene; Kjersti S Rønningen Journal: PLoS One Date: 2011-11-14 Impact factor: 3.240
Authors: Margrit Urbanek; M Geoffrey Hayes; Hoon Lee; Rachel M Freathy; Lynn P Lowe; Christine Ackerman; Nadereh Jafari; Alan R Dyer; Nancy J Cox; David B Dunger; Andrew T Hattersley; Boyd E Metzger; William L Lowe Journal: PLoS One Date: 2012-03-30 Impact factor: 3.240
Authors: Marissa Penna-Martinez; Elizabeth Ramos-Lopez; Inka Robbers; Heinrich Kahles; Stefanie Hahner; Holger Willenberg; Nicole Reisch; Christian Seidl; Maria Segni; Klaus Badenhoop Journal: BMC Med Genet Date: 2009-12-04 Impact factor: 2.103