Literature DB >> 17552555

Imaging pancreatic cancer using surface-functionalized quantum dots.

Jun Qian, Ken-Tye Yong, Indrajit Roy, Tymish Y Ohulchanskyy, Earl J Bergey, Hoon Hi Lee, Kenneth M Tramposch, Sailing He, Anirban Maitra, Paras N Prasad.   

Abstract

In this study, CdSe/CdS/ZnS quantum dots (QDs) were used as optical contrast agent for imaging pancreatic cancer cells in vitro using transferrin and anti-Claudin-4 as targeting ligands. CdSe/CdS/ZnS was chosen because the CdSe/CdS/ZnS QDs have better photoluminescence (PL) efficiency and stability than those of CdSe/ZnS. The transferrin-mediated targeting is demonstrated in both a cell-free coprecipitation assay as well as using in vitro confocal microscopy. Pancreatic cancer specific uptake is also demonstrated using the monoclonal antibody anti-Claudin-4. This targeted QD platform will be further modified for the purpose of developing as an early detection imaging tool for pancreatic cancer.

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Year:  2007        PMID： 17552555     DOI： 10.1021/jp070620n

Source DB:  PubMed          Journal:  J Phys Chem B        ISSN： 1520-5207            Impact factor:   2.991


  19 in total

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Review 5.  Immobilization of biomolecules on the surface of inorganic nanoparticles for biomedical applications.

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6.  Interactions Between Tumor Biology and Targeted Nanoplatforms for Imaging Applications.

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7.  Non-invasive near infrared fluorescence imaging of CdHgTe quantum dots in mouse model.

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Review 10.  Nanoparticles for biomedical imaging.

Authors:  Satish K Nune; Padmaja Gunda; Praveen K Thallapally; Ying-Ying Lin; M Laird Forrest; Cory J Berkland
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