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Literature DB >> 17551815

A pivotal role for p53: balancing aerobic respiration and glycolysis.

Wenzhe Ma¹, Ho Joong Sung, Joon Y Park, Satoaki Matoba, Paul M Hwang.

Abstract

The genetic basis of increased glycolytic activity observed in cancer cells is likely to be the result of complex interactions of multiple regulatory pathways. Here we review the recent evidence of a simple genetic mechanism by which tumor suppressor p53 regulates mitochondrial respiration with secondary changes in glycolysis that are reminiscent of the Warburg effect. The biological significance of this regulation of the two major pathways of energy generation by p53 remains to be seen.

Entities: Disease Gene

Mesh：

Substances：

Year: 2007 PMID： 17551815 DOI： 10.1007/s10863-007-9083-0

Source DB: PubMed Journal: J Bioenerg Biomembr ISSN： 0145-479X Impact factor: 2.945

27 in total

1. p53 is a transcriptional activator of the muscle-specific phosphoglycerate mutase gene and contributes in vivo to the control of its cardiac expression.

Authors: P Ruiz-Lozano; M L Hixon; M W Wagner; A I Flores; S Ikawa; A S Baldwin; K R Chien; A Gualberto
Journal: Cell Growth Differ Date: 1999-05

2. On the origin of cancer cells.

Authors: O WARBURG
Journal: Science Date: 1956-02-24 Impact factor: 47.728

Review 3. p53: 25 years after its discovery.

Authors: Lorne J Hofseth; S Perwez Hussain; Curtis C Harris
Journal: Trends Pharmacol Sci Date: 2004-04 Impact factor: 14.819

4. Requirement for p53 and p21 to sustain G2 arrest after DNA damage.

Authors: F Bunz; A Dutriaux; C Lengauer; T Waldman; S Zhou; J P Brown; J M Sedivy; K W Kinzler; B Vogelstein
Journal: Science Date: 1998-11-20 Impact factor: 47.728

5. The coordinate regulation of the p53 and mTOR pathways in cells.

Authors: Zhaohui Feng; Haiyan Zhang; Arnold J Levine; Shengkan Jin
Journal: Proc Natl Acad Sci U S A Date: 2005-05-31 Impact factor: 11.205

6. AMP-activated protein kinase induces a p53-dependent metabolic checkpoint.

Authors: Russell G Jones; David R Plas; Sara Kubek; Monica Buzzai; James Mu; Yang Xu; Morris J Birnbaum; Craig B Thompson
Journal: Mol Cell Date: 2005-04-29 Impact factor: 17.970

7. Control of cell growth by c-Myc in the absence of cell division.

Authors: M Schuhmacher; M S Staege; A Pajic; A Polack; U H Weidle; G W Bornkamm; D Eick; F Kohlhuber
Journal: Curr Biol Date: 1999-11-04 Impact factor: 10.834

8. Expression of mitochondrial cytochrome c oxidase in human colonic cell differentiation, transformation, and risk for colonic cancer.

Authors: B G Heerdt; H K Halsey; M Lipkin; L H Augenlicht
Journal: Cancer Res Date: 1990-03-01 Impact factor: 12.701

9. High aerobic glycolysis of rat hepatoma cells in culture: role of mitochondrial hexokinase.

Authors: E Bustamante; P L Pedersen
Journal: Proc Natl Acad Sci U S A Date: 1977-09 Impact factor: 11.205

10. The tumor suppressor p53 down-regulates glucose transporters GLUT1 and GLUT4 gene expression.

Authors: Fabiana Schwartzenberg-Bar-Yoseph; Michal Armoni; Eddy Karnieli
Journal: Cancer Res Date: 2004-04-01 Impact factor: 12.701

56 in total

Review 1. p53 regulation of metabolic pathways.

Authors: Eyal Gottlieb; Karen H Vousden
Journal: Cold Spring Harb Perspect Biol Date: 2009-12-02 Impact factor: 10.005

2. Transcriptional changes of mitochondrial genes in irradiated cells proficient or deficient in p53.

Authors: M Ahmad Chaudhry; Romaica A Omaruddin
Journal: J Genet Date: 2012 Impact factor: 1.166

Review 3. p53 and metabolism: old player in a new game.

Authors: Nirmalya Sen; Yatendra Kumar Satija; Sanjeev Das
Journal: Transcription Date: 2012 May-Jun

Review 4. The role of p53 in cell metabolism.

Authors: Xing-ding Zhang; Zheng-hong Qin; Jin Wang
Journal: Acta Pharmacol Sin Date: 2010-08-23 Impact factor: 6.150