BACKGROUND: Despite the widespread use of the sentinel lymph node biopsy technique, many patients with invasive breast cancer still undergo an axillary lymph node dissection and are at risk of arm lymphedema. With the new awareness of lymphatic spread in the axillary nodes, it should be possible to define a new surgical approach between sentinel lymph node biopsy and complete axillary dissection, a procedure preserving specifically lymph nodes in relation to the arm. METHODS: Twenty-one patients with an operable breast cancer requiring an axillary dissection underwent surgery with an attempt to separate nodes related to the breast from specific nodes related to the arm. After an injection of blue dye in the arm, the surgeon performed the axillary dissection trying to identify blue nodes and ducts in order to preserve lymphatic arm drainage (LAD). If the blue nodes were located in the normal axillary dissection, they were removed separately. RESULTS: In 15 of 21 patients (71%), blue nodes in relation with LAD were identified. In 10 (47%) patients, it was possible to dissect the LAD with the preservation lymphatic ducts. In 10 patients, the LAD nodes were removed: none of them contained metastases, despite the fact that the non-LAD axillary nodes contained metastases in 7 of 10 cases. CONCLUSIONS: Identifying the LAD with blue dye injection in the arm is possible. A subsequent study can now begin to determine if this procedure is safe for patients and able to prevent lymphedema of the arm.
BACKGROUND: Despite the widespread use of the sentinel lymph node biopsy technique, many patients with invasive breast cancer still undergo an axillary lymph node dissection and are at risk of arm lymphedema. With the new awareness of lymphatic spread in the axillary nodes, it should be possible to define a new surgical approach between sentinel lymph node biopsy and complete axillary dissection, a procedure preserving specifically lymph nodes in relation to the arm. METHODS: Twenty-one patients with an operable breast cancer requiring an axillary dissection underwent surgery with an attempt to separate nodes related to the breast from specific nodes related to the arm. After an injection of blue dye in the arm, the surgeon performed the axillary dissection trying to identify blue nodes and ducts in order to preserve lymphatic arm drainage (LAD). If the blue nodes were located in the normal axillary dissection, they were removed separately. RESULTS: In 15 of 21 patients (71%), blue nodes in relation with LAD were identified. In 10 (47%) patients, it was possible to dissect the LAD with the preservation lymphatic ducts. In 10 patients, the LAD nodes were removed: none of them contained metastases, despite the fact that the non-LAD axillary nodes contained metastases in 7 of 10 cases. CONCLUSIONS: Identifying the LAD with blue dye injection in the arm is possible. A subsequent study can now begin to determine if this procedure is safe for patients and able to prevent lymphedema of the arm.
Authors: Marlys H Witte; Michael T Dellinger; Donald M McDonald; S David Nathanson; Francesco M Boccardo; Corradino C C Campisi; Jonathan P Sleeman; Jeffrey E Gershenwald Journal: J Surg Oncol Date: 2011-05-01 Impact factor: 3.454
Authors: K Shiva Kumar; G N Hemanth; Poonam K Panjwani; Suraj Manjunath; Rakesh S Ramesh; Rajaram Burrah; Pritilata Rout; D Ramu; Elvis Peter Joseph; Ravi Chandran; C Prasad; Vipin Goel; Supari Divya Journal: Indian J Surg Oncol Date: 2016-11-18
Authors: Jung Woo Han; Yu Jeong Seo; Jung Eun Choi; Su Hwan Kang; Young Kyung Bae; Soo Jung Lee Journal: J Breast Cancer Date: 2012-03-28 Impact factor: 3.588
Authors: Tina W F Yen; Xiaolin Fan; Rodney Sparapani; Purushuttom W Laud; Alonzo P Walker; Ann B Nattinger Journal: Ann Surg Oncol Date: 2009-02-05 Impact factor: 5.344