Literature DB >> 17545586

DNA methylation and complete transcriptional silencing of cancer genes persist after depletion of EZH2.

Kelly M McGarvey1, Eriko Greene, Jill A Fahrner, Thomas Jenuwein, Stephen B Baylin.   

Abstract

Recent work suggests a link between the polycomb group protein EZH2 and mediation of gene silencing in association with maintenance of DNA methylation. However, we show that whereas basally expressed target cancer genes with minimal DNA methylation have increased transcription during EZH2 knockdown, densely DNA hypermethylated and silenced genes retain their methylation and remain transcriptionally silent. These results suggest that EZH2 can modulate transcription of basally expressed genes but not silent genes that are densely DNA methylated.

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Year:  2007        PMID： 17545586     DOI： 10.1158/0008-5472.CAN-06-2029

Source DB:  PubMed          Journal:  Cancer Res        ISSN： 0008-5472            Impact factor:   12.701


  53 in total

Review 1.  Identification of driver and passenger DNA methylation in cancer by epigenomic analysis.

Authors:  Satish Kalari; Gerd P Pfeifer
Journal:  Adv Genet       Date:  2010       Impact factor: 1.944

Review 2.  Linking DNA methylation and histone modification: patterns and paradigms.

Authors:  Howard Cedar; Yehudit Bergman
Journal:  Nat Rev Genet       Date:  2009-05       Impact factor: 53.242

Review 3.  Cross-talk between site-specific transcription factors and DNA methylation states.

Authors:  Adam Blattler; Peggy J Farnham
Journal:  J Biol Chem       Date:  2013-10-22       Impact factor: 5.157

4.  Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line.

Authors:  Einav Nili Gal-Yam; Gerda Egger; Leo Iniguez; Heather Holster; Steingrímur Einarsson; Xinmin Zhang; Joy C Lin; Gangning Liang; Peter A Jones; Amos Tanay
Journal:  Proc Natl Acad Sci U S A       Date:  2008-08-27       Impact factor: 11.205

Review 5.  Chromatin structure of pluripotent stem cells and induced pluripotent stem cells.

Authors:  Paul Delgado-Olguín; Félix Recillas-Targa
Journal:  Brief Funct Genomics       Date:  2011-01       Impact factor: 4.241

6.  Breast cancer-associated fibroblasts confer AKT1-mediated epigenetic silencing of Cystatin M in epithelial cells.

Authors:  Huey-Jen L Lin; Tao Zuo; Ching-Hung Lin; Chieh Ti Kuo; Sandya Liyanarachchi; Shuying Sun; Rulong Shen; Daniel E Deatherage; Dustin Potter; Lisa Asamoto; Shili Lin; Pearlly S Yan; Ann-Lii Cheng; Michael C Ostrowski; Tim H-M Huang
Journal:  Cancer Res       Date:  2008-12-15       Impact factor: 12.701

Review 7.  EZH2: not EZHY (easy) to deal.

Authors:  Gauri Deb; Anup Kumar Singh; Sanjay Gupta
Journal:  Mol Cancer Res       Date:  2014-02-13       Impact factor: 5.852

8.  Comprehensive evaluation of the role of EZH2 in the growth, invasion, and aggression of a panel of prostate cancer cell lines.

Authors:  Breanne D W Karanikolas; Marxa L Figueiredo; Lily Wu
Journal:  Prostate       Date:  2010-05-01       Impact factor: 4.104

9.  Polycomb CBX7 promotes initiation of heritable repression of genes frequently silenced with cancer-specific DNA hypermethylation.

Authors:  Helai P Mohammad; Yi Cai; Kelly M McGarvey; Hariharan Easwaran; Leander Van Neste; Joyce E Ohm; Heather M O'Hagan; Stephen B Baylin
Journal:  Cancer Res       Date:  2009-07-14       Impact factor: 12.701

10.  Functional conservation of Asxl2, a murine homolog for the Drosophila enhancer of trithorax and polycomb group gene Asx.

Authors:  Heather A Baskind; Lucy Na; Quanhong Ma; Mayur P Patel; David L Geenen; Q Tian Wang
Journal:  PLoS One       Date:  2009-03-09       Impact factor: 3.240
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