| Literature DB >> 17544671 |
Laura Franchini1, Pamela Matto, Fiamma Ronchetti, Luigi Panza, Lucia Barbieri, Valeria Costantino, Alfonso Mangoni, Marco Cavallari, Lucia Mori, Gennaro De Libero.
Abstract
A concise synthesis of alpha-sulfatide 1, an analogue of natural glycolipid antigens with potential anti-tumor activity, was performed. Two different approaches to the alpha-glycosidic bond were explored, resulting in a high yield and excellent stereoselectivity. Compound 1 combines the structural features of sulfated beta-GalCer (sulfatide) and alpha-GalCer, which activate specific T cells. alpha-Sulfatide 1 was stimulatory for CD1d-restricted semi-invariant Natural Killer T (iNKT) cell clones, although less potent than alpha-GalCer, while it was not recognized by CD1a-restricted sulfatide-specific T cells.Entities:
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Year: 2007 PMID： 17544671 DOI： 10.1016/j.bmc.2007.05.044
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641