| Literature DB >> 17544282 |
Joe A Tran1, Fabio C Tucci, Wanlong Jiang, Dragan Marinkovic, Caroline W Chen, Melissa Arellano, Stacy Markison, Beth A Fleck, Jenny Wen, Nicole S White, Joseph Pontillo, John Saunders, Daniel Marks, Sam R Hoare, Ajay Madan, Alan C Foster, Chen Chen.
Abstract
A series of pyrrolidinones derived from phenylalanines were synthesized as potent antagonists of the human melanocortin-4 receptor. These compounds showed high potencies and selectivities, and several of them had good oral bioavailabilities. In addition, 12e demonstrated in vivo efficacy in a murine cachexia model.Entities:
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Year: 2007 PMID： 17544282 DOI： 10.1016/j.bmc.2007.05.026
Source DB: PubMed Journal: Bioorg Med Chem ISSN： 0968-0896 Impact factor: 3.641