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Literature DB >> 17542590

Exploiting ligand conformation in selective inhibition of non-ribosomal peptide synthetase amino acid adenylation with designed macrocyclic small molecules.

Justin S Cisar¹, Julian A Ferreras, Rajesh K Soni, Luis E N Quadri, Derek S Tan.

Abstract

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Year: 2007 PMID： 17542590 PMCID： PMC2565600 DOI： 10.1021/ja0721521

Source DB: PubMed Journal: J Am Chem Soc ISSN： 0002-7863 Impact factor: 15.419

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28 in total

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2. Structural basis for the activation of phenylalanine in the non-ribosomal biosynthesis of gramicidin S.

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Review 4. Resistance to antibiotics mediated by target alterations.

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5. Conformationally constrained renin inhibitory peptides: cyclic (3-1)-1-(carboxymethyl)-L-prolyl-L-phenylalanyl-L-histidinamide as a conformational restriction at the P2-P4 tripeptide portion of the angiotensinogen template.

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Review 6. Iron metabolism in pathogenic bacteria.

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7. X-ray crystallographic conformational study of 5'-O-[N-(L-alanyl)-sulfamoyl]adenosine, a substrate analogue for alanyl-tRNA synthetase.

Authors: H Ueda; Y Shoku; N Hayashi; J Mitsunaga; Y In; M Doi; M Inoue; T Ishida
Journal: Biochim Biophys Acta Date: 1991-10-25

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9. Design and synthesis of P2-P1'-linked macrocyclic human renin inhibitors.

Authors: A E Weber; T A Halgren; J J Doyle; R J Lynch; P K Siegl; W H Parsons; W J Greenlee; A A Patchett
Journal: J Med Chem Date: 1991-09 Impact factor: 7.446

10. Cloning and characterization of the gene cluster encoding arthrofactin synthetase from Pseudomonas sp. MIS38.

Authors: Niran Roongsawang; Ken ichi Hase; Mitsuru Haruki; Tadayuki Imanaka; Masaaki Morikawa; Shigenori Kanaya
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Review 2. Small molecule inhibition of microbial natural product biosynthesis-an emerging antibiotic strategy.

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Review 3. Breaking a pathogen's iron will: Inhibiting siderophore production as an antimicrobial strategy.

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4. Expanding the results of a high throughput screen against an isochorismate-pyruvate lyase to enzymes of a similar scaffold or mechanism.

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