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Literature DB >> 17540737

Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies.

Abstract

The long-term effects of metal-on-metal arthroplasty are currently under scrutiny because of the potential biological effects of metal wear debris. This review summarises data describing the release, dissemination, uptake, biological activity, and potential toxicity of metal wear debris released from alloys currently used in modern orthopaedics. The introduction of risk assessment for the evaluation of metal alloys and their use in arthroplasty patients is discussed and this should include potential harmful effects on immunity, reproduction, the kidney, developmental toxicity, the nervous system and carcinogenesis.

Entities: Chemical Disease Species

Mesh：

Substances：
Metals

Year: 2007 PMID： 17540737 DOI： 10.1302/0301-620X.89B5.18903

Source DB: PubMed Journal: J Bone Joint Surg Br ISSN： 0301-620X

Keyword Cloud
Cited

60 in total

1. The John Charnley Award: an accurate and extremely sensitive method to separate, display, and characterize wear debris: part 2: metal and ceramic particles.

Authors: Fabrizio Billi; Paul Benya; Aaron Kavanaugh; John Adams; Harry McKellop; Edward Ebramzadeh
Journal: Clin Orthop Relat Res Date: 2012-02 Impact factor: 4.176

2. Cellular response to prosthetic wear debris differs in patients with and without rheumatoid arthritis.

Authors: Anant Vasudevan; Edward F DiCarlo; Timothy Wright; Dan Chen; Mark P Figgie; Steven R Goldring; Lisa A Mandl
Journal: Arthritis Rheum Date: 2011-11-29

3. Hip resurfacing revision rates: radiological audit of risk factors.

Authors: N Ramisetty; K M Krishnan; P F Partington
Journal: Ann R Coll Surg Engl Date: 2011-05 Impact factor: 1.891

4. Serum titanium, niobium and aluminium levels two years following instrumented spinal fusion in children: does implant surface area predict serum metal ion levels?

Authors: Thomas P Cundy; William J Cundy; Georgia Antoniou; Leanne M Sutherland; Brian J C Freeman; Peter J Cundy
Journal: Eur Spine J Date: 2014-11 Impact factor: 3.134

5. Nanoparticles can cause DNA damage across a cellular barrier.

Authors: Gevdeep Bhabra; Aman Sood; Brenton Fisher; Laura Cartwright; Margaret Saunders; William Howard Evans; Annmarie Surprenant; Gloria Lopez-Castejon; Stephen Mann; Sean A Davis; Lauren A Hails; Eileen Ingham; Paul Verkade; Jon Lane; Kate Heesom; Roger Newson; Charles Patrick Case
Journal: Nat Nanotechnol Date: 2009-12 Impact factor: 39.213

Orthopaedic metals and their potential toxicity in the arthroplasty patient: A review of current knowledge and future strategies.

1. The John Charnley Award: an accurate and extremely sensitive method to separate, display, and characterize wear debris: part 2: metal and ceramic particles.

2. Cellular response to prosthetic wear debris differs in patients with and without rheumatoid arthritis.

3. Hip resurfacing revision rates: radiological audit of risk factors.

4. Serum titanium, niobium and aluminium levels two years following instrumented spinal fusion in children: does implant surface area predict serum metal ion levels?

5. Nanoparticles can cause DNA damage across a cellular barrier.

6. Metal-on-metal: history, state of the art (2010).

Review 7. Mediators of the inflammatory response to joint replacement devices.

8. Metallosis in shoulder arthroplasty: an integrative review of literature.

9. Biocompatibility evaluation of a novel hydroxyapatite-polymer coating for medical implants (in vitro tests).

10. Necrotic and inflammatory changes in metal-on-metal resurfacing hip arthroplasties.