| Literature DB >> 17540368 |
Kamalakar C Nerusu1, Roscoe L Warner, Narasimharao Bhagavathula, Shannon D McClintock, Kent J Johnson, James Varani.
Abstract
Mice lacking matrix metalloproteinase-3 (MMP-3; stromelysin-1) demonstrated significantly less injury than their normal counterparts following the formation of IgG-containing immune complexes in the alveolar wall or in the wall of the peritoneum. Likewise, mice lacking MMP-3 demonstrated less lung injury following intra-tracheal instillation of the chemotactic cytokine macrophage inhibitory protein-2 (MIP-2) than did mice with MMP-3. There was a relationship between tissue injury (evidenced histologically) and accumulation of anti-laminin 111 immunoreactive material in the bronchoalveolar lavage (BAL) or peritoneal lavage (PL) fluid. There was also a relationship between tissue injury and influx of neutrophils into the BAL or PL fluid. Taken together, these data demonstrate an important role for MMP-3 in acute inflammatory tissue injury.Entities:
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Year: 2007 PMID： 17540368 PMCID： PMC2062514 DOI： 10.1016/j.yexmp.2007.04.003
Source DB: PubMed Journal: Exp Mol Pathol ISSN： 0014-4800 Impact factor: 3.362