BACKGROUND: Coronary endothelial dysfunction (CED) and DHF are both associated with myocardial ischemia and CAD risk factors. The objective of the this study was to determine if CED and CAD factors are associated with diastolic dysfunction before the development of occlusive CAD or clinical heart failure. METHODS: Patients with normal ejection fraction and nonocclusive CAD who underwent coronary endothelial function studies were identified. Left ventricular relaxation was assessed by tissue Doppler assessment of early diastolic ascent of the septal mitral annulus (Ea). Multiple linear regression was used to investigate whether coronary risk factors influenced diastolic function after adjusting for the presence of CED. RESULTS: A total of 160 patients had adequate assessment of diastolic relaxation. With multiple linear regression models, %deltaCBF (P = .018) was associated with a higher Ea; in contrast, older age (P < .001), female sex (P = .028), higher left ventricular mass index (P = .016), and higher nonhigh-density lipoprotein cholesterol (P = .022) were associated with a lower Ea. CONCLUSION: Coronary endothelial dysfunction and hyperlipidemia are independently associated with impaired relaxation in patients with normal ejection fraction in the absence of occlusive CAD and heart failure. The current study suggests a new potential mechanism for the development of endothelial and diastolic dysfunction in humans.
BACKGROUND:Coronary endothelial dysfunction (CED) and DHF are both associated with myocardial ischemia and CAD risk factors. The objective of the this study was to determine if CED and CAD factors are associated with diastolic dysfunction before the development of occlusive CAD or clinical heart failure. METHODS:Patients with normal ejection fraction and nonocclusive CAD who underwent coronary endothelial function studies were identified. Left ventricular relaxation was assessed by tissue Doppler assessment of early diastolic ascent of the septal mitral annulus (Ea). Multiple linear regression was used to investigate whether coronary risk factors influenced diastolic function after adjusting for the presence of CED. RESULTS: A total of 160 patients had adequate assessment of diastolic relaxation. With multiple linear regression models, %deltaCBF (P = .018) was associated with a higher Ea; in contrast, older age (P < .001), female sex (P = .028), higher left ventricular mass index (P = .016), and higher nonhigh-density lipoprotein cholesterol (P = .022) were associated with a lower Ea. CONCLUSION:Coronary endothelial dysfunction and hyperlipidemia are independently associated with impaired relaxation in patients with normal ejection fraction in the absence of occlusive CAD and heart failure. The current study suggests a new potential mechanism for the development of endothelial and diastolic dysfunction in humans.
Authors: Calvin W L Chin; Chee-Yang Chin; Marie X R Ng; Thu-Thao Le; Fei-Qiong Huang; Kok-Yong Fong; Julian Thumboo; Ru-San Tan Journal: Rheumatol Int Date: 2014-02-19 Impact factor: 2.631
Authors: Lai Ming Yung; Wing Tak Wong; Xiao Yu Tian; Fung Ping Leung; Lai Hang Yung; Zhen Yu Chen; Xiaoqiang Yao; Chi Wai Lau; Yu Huang Journal: PLoS One Date: 2011-03-29 Impact factor: 3.240
Authors: Jingmin Zhou; Xiaotong Cui; Xuejuan Jin; Jun Zhou; Hanying Zhang; Bixiao Tang; Michael Fu; Hans Herlitz; Jie Cui; Hongmin Zhu; Aijun Sun; Kai Hu; Junbo Ge Journal: PLoS One Date: 2014-02-12 Impact factor: 3.240