Literature DB >> 17540167

Filling a GAP(DH) in caspase-independent cell death.

Jeffrey C Rathmell1, Sally Kornbluth.   

Abstract

Mitochondrial outer-membrane permeabilization can lead to cell death even without activation of caspases. In this issue of Cell, Colell et al. (2007) identify the glycolytic enzyme glyceraldehyde-3-phosphate dehydrogenase as a potent inhibitor of caspase-independent cell death that may allow metabolically active cells to survive mitochondrial insult.

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Year:  2007        PMID： 17540167      PMCID： PMC2592604          DOI： 10.1016/j.cell.2007.05.030

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  8 in total

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