OBJECTIVE: To determine whether dronabinol affects appetite and weight status in patients living with HIV/AIDS. METHODS: A retrospective chart review was conducted to analyze weight and appetite changes and nausea status in patients with HIV/AIDS who received dronabinol for 3 to 12 months from January 11, 1993, to March 17, 2003. RESULTS: Of the 117 patients who lost weight before baseline, 63% maintained or gained weight. In patients receiving dronabinol for 1 year, the mean weight gain (+/- SD) was 3.7 +/- 10.6 lb. The percentage of patients experiencing loss of appetite decreased significantly from 71% at baseline to 26% at 1 month (P < .001) and continued to decline throughout the trial. The percentage of patients experiencing nausea at baseline (38%) decreased consistently from week 2 on; this change from baseline was significant at month 6 (P = .031). CONCLUSION: When taken for 3 months to 1 year, dronabinol significantly improves appetite and reverses weight loss in patients living with HIV/AIDS.
OBJECTIVE: To determine whether dronabinol affects appetite and weight status in patients living with HIV/AIDS. METHODS: A retrospective chart review was conducted to analyze weight and appetite changes and nausea status in patients with HIV/AIDS who received dronabinol for 3 to 12 months from January 11, 1993, to March 17, 2003. RESULTS: Of the 117 patients who lost weight before baseline, 63% maintained or gained weight. In patients receiving dronabinol for 1 year, the mean weight gain (+/- SD) was 3.7 +/- 10.6 lb. The percentage of patients experiencing loss of appetite decreased significantly from 71% at baseline to 26% at 1 month (P < .001) and continued to decline throughout the trial. The percentage of patients experiencing nausea at baseline (38%) decreased consistently from week 2 on; this change from baseline was significant at month 6 (P = .031). CONCLUSION: When taken for 3 months to 1 year, dronabinol significantly improves appetite and reverses weight loss in patients living with HIV/AIDS.
Authors: Angela M Amedee; Whitney A Nichols; Nicole J LeCapitaine; Curtis Vande Stouwe; Leslie L Birke; Nedra Lacour; Peter J Winsauer; Patricia E Molina Journal: AIDS Res Hum Retroviruses Date: 2014-12 Impact factor: 2.205
Authors: Ersilia M DeFilippis; Navkaranbir S Bajaj; Amitoj Singh; Rhynn Malloy; Michael M Givertz; Ron Blankstein; Deepak L Bhatt; Muthiah Vaduganathan Journal: J Am Coll Cardiol Date: 2020-01-28 Impact factor: 24.094
Authors: Chaela Presley; Ammaar Abidi; Satyendra Suryawanshi; Suni Mustafa; Bernd Meibohm; Bob M Moore Journal: Pharmacol Res Perspect Date: 2015-07-06