| Literature DB >> 31976871 |
Ersilia M DeFilippis1, Navkaranbir S Bajaj2, Amitoj Singh3, Rhynn Malloy4, Michael M Givertz4, Ron Blankstein5, Deepak L Bhatt6, Muthiah Vaduganathan7.
Abstract
Marijuana use is increasing as more states are legalizing cannabis for both medicinal and recreational purposes. National survey data estimate that >2 million Americans with established cardiovascular diseases currently use or have used marijuana in its variety of forms, including inhalation and vaping. Cannabinoid receptors are distributed in multiple tissue beds and cells, including platelets, adipose tissue, and myocytes. Observational data suggest associations between marijuana and a broad range of adverse cardiovascular risks. Marijuana is becoming increasingly potent, and smoking marijuana carries many of the same cardiovascular health hazards as smoking tobacco. Synthetic cannabinoids have been linked to more sustained and deleterious pharmacodynamic effects. Marijuana is classified as a Schedule I substance, thus limiting its rigorous study for cardiovascular health effects. This review summarizes cardiovascular considerations related to marijuana use, pharmacological interactions, and future steps to provide clearer guidance regarding its cardiovascular safety. Screening for marijuana use is encouraged, especially in young patients presenting with cardiovascular disease.Entities:
Keywords: arrhythmia; cannabis; coronary artery disease; marijuana; vascular disease
Mesh：
Year: 2020 PMID： 31976871 PMCID： PMC7977484 DOI： 10.1016/j.jacc.2019.11.025
Source DB: PubMed Journal: J Am Coll Cardiol ISSN： 0735-1097 Impact factor: 24.094