Literature DB >> 1752779

Human tumor-infiltrating lymphocytes transfected with tumor necrosis factor gene could augment cytotoxicity to autologous tumor cells.

Y Itoh1, Y Kohgo, N Watanabe, Y Kanisawa, S Sakamaki, M Takahashi, Y Hirayama, H Ono, T Himeno, Y Niitsu.   

Abstract

Human tumor-infiltrating lymphocytes (TILs) derived from pleural or ascitic fluid were incubated with recombinant interleukin 2 and transfected with human tumor necrosis factor (TNF) alpha gene by the lipofection procedure. The resulting TILs secreted significant amounts of TNF in the culture supernatant and exhibited cytotoxicity against established cell lines, such as K562 and Daudi, and autologous tumor cells. The TNF gene-transfected TILs exhibited an augmented killing of autologous tumor cells.

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Year:  1991        PMID： 1752779      PMCID： PMC5918323          DOI： 10.1111/j.1349-7006.1991.tb01781.x

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  17 in total

1.  Proposal of standardized methods and reference for assaying recombinant human tumor necrosis factor.

Authors:  S Yamazaki; E Onishi; K Enami; K Natori; M Kohase; H Sakamoto; M Tanouchi; H Hayashi
Journal:  Jpn J Med Sci Biol       Date:  1986-06

2.  Gene transfer into humans--immunotherapy of patients with advanced melanoma, using tumor-infiltrating lymphocytes modified by retroviral gene transduction.

Authors:  S A Rosenberg; P Aebersold; K Cornetta; A Kasid; R A Morgan; R Moen; E M Karson; M T Lotze; J C Yang; S L Topalian
Journal:  N Engl J Med       Date:  1990-08-30       Impact factor: 91.245

3.  Recombinant human TNF induces production of granulocyte-monocyte colony-stimulating factor.

Authors:  R Munker; J Gasson; M Ogawa; H P Koeffler
Journal:  Nature       Date:  1986 Sep 4-10       Impact factor: 49.962

4.  Cytokines alter target cell susceptibility to lysis. II. Evaluation of tumor infiltrating lymphocytes.

Authors:  H Stötter; E A Wiebke; S Tomita; A Belldegrun; S Topalian; S A Rosenberg; M T Lotze
Journal:  J Immunol       Date:  1989-03-01       Impact factor: 5.422

5.  Synergy of tumor necrosis factor and interleukin 2 in the activation of human cytotoxic lymphocytes: effect of tumor necrosis factor alpha and interleukin 2 in the generation of human lymphokine-activated killer cell cytotoxicity.

Authors:  L B Owen-Schaub; J U Gutterman; E A Grimm
Journal:  Cancer Res       Date:  1988-02-15       Impact factor: 12.701

6.  Tumor localization of adoptively transferred indium-111 labeled tumor infiltrating lymphocytes in patients with metastatic melanoma.

Authors:  B Fisher; B S Packard; E J Read; J A Carrasquillo; C S Carter; S L Topalian; J C Yang; P Yolles; S M Larson; S A Rosenberg
Journal:  J Clin Oncol       Date:  1989-02       Impact factor: 44.544

7.  Expression of endogenous tumor necrosis factor as a protective protein against the cytotoxicity of exogenous tumor necrosis factor.

Authors:  T Himeno; N Watanabe; N Yamauchi; M Maeda; Y Tsuji; T Okamoto; H Neda; Y Niitsu
Journal:  Cancer Res       Date:  1990-08-15       Impact factor: 12.701

8.  Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells.

Authors:  N Watanabe; Y Niitsu; H Neda; H Sone; N Yamauchi; T Umetsu; I Urushizaki
Journal:  Jpn J Cancer Res       Date:  1985-11

9.  Functional interactions of IL2 and TNF in the differentiation of LGL into LAK effectors.

Authors:  J Y Blay; J Bertoglio; D Fradelizi; S Chouaib
Journal:  Int J Cancer       Date:  1989-10-15       Impact factor: 7.396

10.  Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Authors:  C A Dinarello; J G Cannon; S M Wolff; H A Bernheim; B Beutler; A Cerami; I S Figari; M A Palladino; J V O'Connor
Journal:  J Exp Med       Date:  1986-06-01       Impact factor: 14.307
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  3 in total

1.  Activation of tumor-infiltrating macrophages by a synthetic lipid A analog (ONO-4007) and its implication in antitumor effects.

Authors:  D Yang; M Satoh; H Ueda; S Tsukagoshi; M Yamazaki
Journal:  Cancer Immunol Immunother       Date:  1994-05       Impact factor: 6.968

2.  Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production.

Authors:  Y Itoh; Y Koshita; M Takahashi; N Watanabe; Y Kohgo; Y Niitsu
Journal:  Cancer Immunol Immunother       Date:  1995-02       Impact factor: 6.968

3.  Augmented systemic immunity in mice implanted with tumor necrosis factor-alpha gene-transduced Meth-A-cells.

Authors:  S Fujii; Y Liu; H Neda; Y Itoh; Y Koshita; M Takahashi; N Watanabe; Y Kohgo; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1994-03
  3 in total

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