Literature DB >> 3936830

Antitumor effect of tumor necrosis factor against various primarily cultured human cancer cells.

N Watanabe, Y Niitsu, H Neda, H Sone, N Yamauchi, T Umetsu, I Urushizaki.   

Abstract

The antitumor activity of tumor necrosis factor (TNF) against various primarily cultured human cancer cells (32 cases) was investigated by the 51Cr cytotoxic release assay and the tumor stem cell assay. Over 50% sensitivity (the ratio to the cytotoxicity in L929 cells) was noted in 4 of 14 cases of gastric cancer (28.6%), 7 of 9 cases of leukemic cells (77.8%), and 1 case each of pancreatic carcinoma and ovarian cancer. Scarcely any sensitivity, however, was observed in 1 case of acute promyelocytic leukemia or in some of the gastric cancer cases. No correlation was observed between the histological type of the cancer and TNF sensitivity. The above results seem to confirm that TNF has significant antitumor activity against human cancer cells.

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Year:  1985        PMID： 3936830

Source DB:  PubMed          Journal:  Jpn J Cancer Res        ISSN： 0910-5050


  14 in total

1.  Glutathione and the rate of cellular proliferation determine tumour cell sensitivity to tumour necrosis factor in vivo.

Authors:  E Obrador; J Navarro; J Mompo; M Asensi; J A Pellicer; J M Estrela
Journal:  Biochem J       Date:  1997-07-01       Impact factor: 3.857

2.  Signalling pathway of tumor necrosis factor in normal and tumor cells.

Authors:  N Watanabe; H Neda; Y Ohtusuka; H Sone; N Yamauchi; M Maeda; H Kuriyama; Y Niitsu
Journal:  Cancer Immunol Immunother       Date:  1989       Impact factor: 6.968

3.  Sensitization of human malignant glioma cell lines to tumor necrosis factor-induced apoptosis by cisplatin.

Authors:  L Duan; M Aoyagi; M Tamaki; K Nakagawa; G Nagashima; Y Nagasaka; K Ohno; K Yamamoto; K Hirakawa
Journal:  J Neurooncol       Date:  2001-03       Impact factor: 4.130

4.  Cycloheximide-induced modulation of TNF-mediated cytotoxicity in sensitive and resistant ovarian tumor cells.

Authors:  Y Nio; J Zighelboim; J Berek; B Bonavida
Journal:  Cancer Chemother Pharmacol       Date:  1990       Impact factor: 3.333

Review 5.  Hyperthermic modulation of macrophage-tumor cell interactions.

Authors:  S P Tomasovic; J Klostergaard
Journal:  Cancer Metastasis Rev       Date:  1989-12       Impact factor: 9.264

6.  Specificity of tumor necrosis factor toxicity for human mammary carcinomas relative to normal mammary epithelium and correlation with response to doxorubicin.

Authors:  C Dollbaum; A A Creasey; S H Dairkee; A J Hiller; A R Rudolph; L Lin; C Vitt; H S Smith
Journal:  Proc Natl Acad Sci U S A       Date:  1988-07       Impact factor: 11.205

7.  Characterization of tumor-necrosis-factor-gene-transduced tumor-infiltrating lymphocytes from ascitic fluid of cancer patients: analysis of cytolytic activity, growth rate, adhesion molecule expression and cytokine production.

Authors:  Y Itoh; Y Koshita; M Takahashi; N Watanabe; Y Kohgo; Y Niitsu
Journal:  Cancer Immunol Immunother       Date:  1995-02       Impact factor: 6.968

8.  Antitumor effects of recombinant human tumor necrosis factor against human tumor xenografts transplanted into nude mice.

Authors:  Y Nosoh; T Toge; M Nishiyama; M Yamaguchi; N Hirabayashi; M Niimoto; T Hattori
Journal:  Jpn J Surg       Date:  1987-01

9.  Prolactin, TNF alpha and nitric oxide expression in nitroso-N-methylurea-induced-mammary tumours.

Authors:  Irene Vegh; Rafael Enríquez de Salamanca
Journal:  J Carcinog       Date:  2007-11-28

10.  Reversal of tumor necrosis factor resistance in tumor cells by adriamycin via suppression of intracellular resistance factors.

Authors:  N Watanabe; T Okamoto; N Tsuji; H Sasaki; S Akiyama; D Kobayashi; T Sato; N Yamauchi; Y Niitsu
Journal:  Jpn J Cancer Res       Date:  1995-04
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