PURPOSE: To investigate the efficacy of tunneled scleral incision compared with standard straight scleral incision to prevent vitreal reflux after intravitreal (IVT) injection. DESIGN: Prospective comparative controlled nonrandomized clinical study. METHODS:Eighty-eight eyes undergoing IVT-injection were allocated into four groups to compare the vitreal reflux after injection of 0.1 ml of triamcinolone acetonide (TA) and Avastin using a tunneled vs straight injection technique. The amount of intraoperative drug reflux was estimated by measuring the width of the subconjunctival bleb. RESULTS: The mean measured reflux of volume was statistically less with the tunneled scleral incision (1.13 mm standard deviation [SD] +/- 1.16 for TA; 1.13 mm SD +/- 1.39 for Avastin) than in eyes undergoing the straight scleral injection (3.00 mm SD +/- 1.77 for TA; 3.18 mm SD +/- 1.68 for Avastin) for both Avastin and TA IVT-injections groups (P < .001). CONCLUSIONS: The tunneled scleral incision promotes statistically significant less vitreal reflux for IVT drug injection.
RCT Entities:
PURPOSE: To investigate the efficacy of tunneled scleral incision compared with standard straight scleral incision to prevent vitreal reflux after intravitreal (IVT) injection. DESIGN: Prospective comparative controlled nonrandomized clinical study. METHODS: Eighty-eight eyes undergoing IVT-injection were allocated into four groups to compare the vitreal reflux after injection of 0.1 ml of triamcinolone acetonide (TA) and Avastin using a tunneled vs straight injection technique. The amount of intraoperative drug reflux was estimated by measuring the width of the subconjunctival bleb. RESULTS: The mean measured reflux of volume was statistically less with the tunneled scleral incision (1.13 mm standard deviation [SD] +/- 1.16 for TA; 1.13 mm SD +/- 1.39 for Avastin) than in eyes undergoing the straight scleral injection (3.00 mm SD +/- 1.77 for TA; 3.18 mm SD +/- 1.68 for Avastin) for both Avastin and TA IVT-injections groups (P < .001). CONCLUSIONS: The tunneled scleral incision promotes statistically significant less vitreal reflux for IVT drug injection.
Authors: Carsten H Meyer; Zengping Liu; Christian K Brinkmann; Eduardo B Rodrigues; Thomas Bertelmann Journal: J Ocul Pharmacol Ther Date: 2014-05-06 Impact factor: 2.671
Authors: Frank L Brodie; Jason Ruggiero; Devon H Ghodasra; Kian Eftekhari; James Z Hui; Alexander J Brucker; Brian L VanderBeek Journal: Curr Eye Res Date: 2013-11-20 Impact factor: 2.424