| Literature DB >> 1752289 |
R T Cunningham1, I S Young, J Winder, M J O'Kane, S McKinstry, C F Johnston, O M Dolan, S A Hawkins, K D Buchanan.
Abstract
A radioimmunoassay has been developed and used to measure serum neurone specific enolase (NSE) concentrations in 24 patients, following cerebral infarction. A significant correlation between cerebral infarct volume and maximum serum NSE concentration was observed (P = 0.047). Serum NSE was also assayed at times 24, 48, 72 and 96 h post ictus. At 72 h a significant correlation existed between serum NSE levels and infarct volume (P = 0.012), and levels appeared to be approaching statistical significance at 48 h (P = 0.067). No correlation existed at 24 and 96 h. In addition serum concentrations of NSE were compared to clinical outcome as determined by the Glasgow Outcome Score. Using the Mann-Whitney U test, there was no significant difference in maximum NSE level between patients graded 1-3 on the Glasgow Outcome Score and those graded 4 and 5. However, further studies are required on a larger population to more completely assess this. NSE may prove to be a useful marker of neuronal damage in the study of stroke, with particular application in the assessment of treatment.Entities:
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Year: 1991 PMID： 1752289 DOI： 10.1111/j.1365-2362.1991.tb01401.x
Source DB: PubMed Journal: Eur J Clin Invest ISSN： 0014-2972 Impact factor: 4.686