Literature DB >> 17518542

Aging delays the regeneration process following sciatic nerve injury in rats.

Yong-Jun Wang1, Chong-Jian Zhou, Qi Shi, Nathan Smith, Tian-Fang Li.   

Abstract

The present study investigated the effect of aging on muscle reinnervation in rats following a crush nerve injury. Using confocal laser scanning microscopy, we examined the spatial correlation of terminal Schwann cells (TSCs) or axon terminals with acetylcholine receptor (AChR) sites at neuromuscular junctions (NMJs). Compared to young rats (4 months of age), aged rats (24 months of age) demonstrated damaged TSC extensions and delayed regeneration. Post-injury endplate abnormalities in aged rats correlated with the degree of TSC degeneration. In the late stages of reinnervation, pathologic changes were seen in old rats, including multiple innervations, terminal sprouting, and poorly formed collateral innervation in NMJs. Our results suggest that the impaired TSC-axon interaction in aged rats delays the reinnervation process.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17518542     DOI： 10.1089/neu.2006.0156

Source DB:  PubMed          Journal:  J Neurotrauma        ISSN： 0897-7151            Impact factor:   5.269


  8 in total

1.  How age impairs the response of the neuromuscular junction to nerve transection and repair: An experimental study in rats.

Authors:  Peter J Apel; Timothy Alton; Casey Northam; Jianjun Ma; Michael Callahan; William E Sonntag; Zhongyu Li
Journal:  J Orthop Res       Date:  2009-03       Impact factor: 3.494

2.  Effect of locally delivered IGF-1 on nerve regeneration during aging: an experimental study in rats.

Authors:  Peter J Apel; Jianjun Ma; Michael Callahan; Casey N Northam; Timothy B Alton; William E Sonntag; Zhongyu Li
Journal:  Muscle Nerve       Date:  2010-03       Impact factor: 3.217

3.  Comprehensive Analysis of Age-related Changes in Lipid Metabolism and Myelin Sheath Formation in Sciatic Nerves.

Authors:  David Djuanda; Bo He; Xiangxia Liu; Shuqia Xu; Yi Zhang; Yangbin Xu; Zhaowei Zhu
Journal:  J Mol Neurosci       Date:  2021-01-25       Impact factor: 3.444

4.  Aging Induces Changes in the Somatic Nerve and Postsynaptic Component without Any Alterations in Skeletal Muscles Morphology and Capacity to Carry Load of Wistar Rats.

Authors:  Walter Krause Neto; Wellington de Assis Silva; Adriano P Ciena; Romeu R de Souza; Carlos A Anaruma; Eliane F Gama
Journal:  Front Neurosci       Date:  2017-12-18       Impact factor: 4.677

5.  Effects of Strength Training and Anabolic Steroid in the Peripheral Nerve and Skeletal Muscle Morphology of Aged Rats.

Authors:  Walter Krause Neto; Wellington de A Silva; Adriano P Ciena; Ricardo Aparecido Baptista Nucci; Carlos A Anaruma; Eliane F Gama
Journal:  Front Aging Neurosci       Date:  2017-06-30       Impact factor: 5.750

Review 6.  Age and/or postmenopausal status as risk factors for pelvic organ prolapse development: systematic review with meta-analysis.

Authors:  Luiz Gustavo Oliveira Brito; Glaucia Miranda Varella Pereira; Pamela Moalli; Oksana Shynlova; Jittima Manonai; Adi Yehuda Weintraub; Jan Deprest; Maria Augusta T Bortolini
Journal:  Int Urogynecol J       Date:  2021-08-05       Impact factor: 1.932

7.  Inflammaging impairs peripheral nerve maintenance and regeneration.

Authors:  Robert Büttner; Alexander Schulz; Michael Reuter; Asha K Akula; Thomas Mindos; Annemarie Carlstedt; Lars B Riecken; Stephan L Baader; Reinhard Bauer; Helen Morrison
Journal:  Aging Cell       Date:  2018-08-31       Impact factor: 9.304

Review 8.  The Neuromuscular Junction: Roles in Aging and Neuromuscular Disease.

Authors:  Shama R Iyer; Sameer B Shah; Richard M Lovering
Journal:  Int J Mol Sci       Date:  2021-07-28       Impact factor: 5.923
  8 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.