| Literature DB >> 19802878 |
Peter J Apel1, Jianjun Ma, Michael Callahan, Casey N Northam, Timothy B Alton, William E Sonntag, Zhongyu Li.
Abstract
Age is an important predictor of neuromuscular recovery after peripheral nerve injury. Insulin-like growth factor 1 (IGF-1) is a potent neurotrophic factor that is known to decline with increasing age. The purpose of this study was to determine if locally delivered IGF-1 would improve nerve regeneration and neuromuscular recovery in aged animals. Young and aged rats underwent nerve transection and repair with either saline or IGF-1 continuously delivered to the site of the nerve repair. After 3 months, nerve regeneration and neuromuscular junction morphology were assessed. In both young and aged animals, IGF-1 significantly improved axon number, diameter, and density. IGF-1 also significantly increased myelination and Schwann cell activity and preserved the morphology of the postsynaptic neuromuscular junction (NMJ). These results show that aged regenerating nerve is sensitive to IGF-1 treatment.Entities:
Mesh：
Substances：
Year: 2010 PMID： 19802878 PMCID： PMC3045758 DOI： 10.1002/mus.21485
Source DB: PubMed Journal: Muscle Nerve ISSN： 0148-639X Impact factor: 3.217