| Literature DB >> 17517840 |
Yanjun Li1, M Hong Nguyen, Hartmut Derendorf, Shaoji Cheng, Cornelius J Clancy.
Abstract
We developed a high-performance liquid chromatography (HPLC) assay to validate time-kill and postantifungal-effect (PAFE) experiments for voriconazole against Candida albicans, Candida glabrata, and Candida parapsilosis isolates. Voriconazole exerted prolonged fungistatic activity but no PAFE at concentrations achievable in human sera. HPLC confirmed that experiments were conducted at the desired steady-state voriconazole concentrations.Entities:
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Year: 2007 PMID: 17517840 PMCID: PMC1932531 DOI: 10.1128/AAC.00308-07
Source DB: PubMed Journal: Antimicrob Agents Chemother ISSN: 0066-4804 Impact factor: 5.191