Literature DB >> 17517833

Interdomain loop mutation Asp190Cys of the tetracycline efflux transporter TetA(B) decreases affinity for substrate.

Frédéric M Sapunaric, Stuart B Levy.   

Abstract

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17517833      PMCID： PMC1932504          DOI： 10.1128/AAC.00357-07

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


× No keyword cloud information.
  13 in total

1.  Mutations in the interdomain loop region of the tetA(A) tetracycline resistance gene increase efflux of minocycline and glycylcyclines.

Authors:  M Tuckman; P J Petersen; S J Projan
Journal:  Microb Drug Resist       Date:  2000       Impact factor: 3.431

2.  Complete cysteine-scanning mutagenesis and site-directed chemical modification of the Tn10-encoded metal-tetracycline/H+ antiporter.

Authors:  N Tamura; S Konishi; S Iwaki; T Kimura-Someya; S Nada; A Yamaguchi
Journal:  J Biol Chem       Date:  2001-02-06       Impact factor: 5.157

3.  Substitutions in the interdomain loop of the Tn10 TetA efflux transporter alter tetracycline resistance and substrate specificity.

Authors:  Frédéric M Sapunaric; Stuart B Levy
Journal:  Microbiology (Reading)       Date:  2005-07       Impact factor: 2.777

4.  Stoichiometry of metal-tetracycline/H+ antiport mediated by transposon Tn10-encoded tetracycline resistance protein in Escherichia coli.

Authors:  A Yamaguchi; Y Iwasaki-Ohba; N Ono; M Kaneko-Ohdera; T Sawai
Journal:  FEBS Lett       Date:  1991-05-06       Impact factor: 4.124

Review 5.  Proton-dependent multidrug efflux systems.

Authors:  I T Paulsen; M H Brown; R A Skurray
Journal:  Microbiol Rev       Date:  1996-12

6.  Role of the charge interaction between Arg(70) and Asp(120) in the Tn10-encoded metal-tetracycline/H(+) antiporter of Escherichia coli.

Authors:  Y Someya; T Kimura-Someya; A Yamaguchi
Journal:  J Biol Chem       Date:  2000-01-07       Impact factor: 5.157

7.  Mercaptide formed between the residue Cys70 and Hg2+ or Co2+ behaves as a functional positively charged side chain operative in the Arg70-->Cys mutant of the metal-tetracycline/H+ antiporter of Escherichia coli.

Authors:  Y Someya; A Yamaguchi
Journal:  Biochemistry       Date:  1996-07-23       Impact factor: 3.162

8.  Catalytic mechanism of active-site serine beta-lactamases: role of the conserved hydroxy group of the Lys-Thr(Ser)-Gly triad.

Authors:  A Dubus; J M Wilkin; X Raquet; S Normark; J M Frère
Journal:  Biochem J       Date:  1994-07-15       Impact factor: 3.857

9.  Second-site suppressor mutations for the serine 202 to phenylalanine substitution within the interdomain loop of the tetracycline efflux protein Tet(C).

Authors:  Frederic M Sapunaric; Stuart B Levy
Journal:  J Biol Chem       Date:  2003-05-23       Impact factor: 5.157

10.  Second-site mutation of Ala-220 to Glu or Asp suppresses the mutation of Asp-285 to Asn in the transposon Tn10-encoded metal-tetracycline/H+ antiporter of Escherichia coli.

Authors:  A Yamaguchi; R O'yauchi; Y Someya; T Akasaka; T Sawai
Journal:  J Biol Chem       Date:  1993-12-25       Impact factor: 5.157
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.