| Literature DB >> 17517426 |
Jocivânia O da Silva1, Renata S Fernandes, Fábio K Ticli, Clayton Z Oliveira, Maurício V Mazzi, João J Franco, Silvana Giuliatti, Paulo S Pereira, Andreimar M Soares, Suely V Sampaio.
Abstract
We report here the antiproteolytic and antihemorrhagic properties of triterpenoid saponin inhibitors, named macrolobin-A and B, from Pentaclethra macroloba, against Bothrops snake venoms. The inhibitors were able to neutralize the hemorrhagic, fibrin(ogen)olytic, and proteolytic activities of class P-I and P-III metalloproteases isolated from B. neuwiedi and B. jararacussu venoms. Clotting and fibrinogenolytic activities induced by snake venoms and isolated thrombin-like enzymes were partially inhibited. Furthermore, the potential use of these inhibitors to complement antivenom therapy as an alternative treatment and/or used as molecular models for development of new therapeutical agents in the treatment of snake bite envenomations needs to be evaluated in future studies.Entities:
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Year: 2007 PMID： 17517426 DOI： 10.1016/j.toxicon.2007.03.024
Source DB: PubMed Journal: Toxicon ISSN： 0041-0101 Impact factor: 3.033