OBJECTIVE: To compare the clinical outcomes after day 4 or day 3 embryo transfers in controlled ovarian hyperstimulation-IVF/intracytoplasmic sperm injection (ICSI) cycles. DESIGN: Prospective randomized study. SETTING: Center for Human Reproduction, 'Genesis Athens' Clinic (private gynecological and surgical clinic), Athens, Greece. PATIENT(S): Three hundred fifty women with primary infertility and indication for IVF/ICSI treatment. Patients were randomly allocated to day 4 or day 3 embryo transfer. INTERVENTION(S): Controlled ovarian hyperstimulation, oocyte retrieval, IVF/ICSI, embryo transfer. MAIN OUTCOME MEASURE(S): Implantation rate; clinical, ongoing, and multiple pregnancy rates. RESULT(S): A trend toward higher clinical and ongoing pregnancy rates was noted after day 4 embryo transfers. Implantation and multiple pregnancy rates were comparable after day 4 or day 3 embryo transfers. CONCLUSION(S): The transfer of day 4 embryos in IVF/ICSI cycles may result in favorable implantation and pregnancy rates which are at least comparable to those after the transfer of day 3 embryos.
RCT Entities:
OBJECTIVE: To compare the clinical outcomes after day 4 or day 3 embryo transfers in controlled ovarian hyperstimulation-IVF/intracytoplasmic sperm injection (ICSI) cycles. DESIGN: Prospective randomized study. SETTING: Center for Human Reproduction, 'Genesis Athens' Clinic (private gynecological and surgical clinic), Athens, Greece. PATIENT(S): Three hundred fifty women with primary infertility and indication for IVF/ICSI treatment. Patients were randomly allocated to day 4 or day 3 embryo transfer. INTERVENTION(S): Controlled ovarian hyperstimulation, oocyte retrieval, IVF/ICSI, embryo transfer. MAIN OUTCOME MEASURE(S): Implantation rate; clinical, ongoing, and multiple pregnancy rates. RESULT(S): A trend toward higher clinical and ongoing pregnancy rates was noted after day 4 embryo transfers. Implantation and multiple pregnancy rates were comparable after day 4 or day 3 embryo transfers. CONCLUSION(S): The transfer of day 4 embryos in IVF/ICSI cycles may result in favorable implantation and pregnancy rates which are at least comparable to those after the transfer of day 3 embryos.
Authors: M Simopoulou; K Sfakianoudis; P Tsioulou; A Rapani; E Maziotis; P Giannelou; S Grigoriadis; A Pantou; K Nikolettos; N Vlahos; K Pantos; M Koutsilieris Journal: J Assist Reprod Genet Date: 2019-05-20 Impact factor: 3.412