Literature DB >> 1751423

Antibodies to human leucocyte antigens indicate subpopulations of microglia in human retina.

P L Penfold1, M C Madigan, J M Provis.   

Abstract

Monoclonal antibodies to human leucocyte antigens, including anti-CD45 and anti-CD68, have been used to describe microglia in flatmounts of normal adult human retina for the first time. Anti-CD45 (the leucocyte common antigen) intensely labeled large numbers of cells in a regular distribution across the retina; anti-CD68 and anti-macrophage antibodies labeled fewer cells with distinctive morphologies, suggesting the presence of subpopulations of microglia in the human retina expressing leucocyte antigens.

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Year:  1991        PMID： 1751423     DOI： 10.1017/s0952523800004879

Source DB:  PubMed          Journal:  Vis Neurosci        ISSN： 0952-5238            Impact factor:   3.241


  9 in total

1.  RNA-sequencing reveals oligodendrocyte and neuronal transcripts in microglia relevant to central nervous system disease.

Authors:  Anne C Solga; Winnie W Pong; Jason Walker; Todd Wylie; Vincent Magrini; Anthony J Apicelli; Malachi Griffith; Obi L Griffith; Shinichi Kohsaka; Gregory F Wu; David L Brody; Elaine R Mardis; David H Gutmann
Journal:  Glia       Date:  2014-09-24       Impact factor: 7.452

2.  Microglia in the primate macula: specializations in microglial distribution and morphology with retinal position and with aging.

Authors:  Janani Singaravelu; Lian Zhao; Robert N Fariss; T Michael Nork; Wai T Wong
Journal:  Brain Struct Funct       Date:  2017-02-17       Impact factor: 3.270

3.  Abundance of infiltrating CD163+ cells in the retina of postmortem eyes with dry and neovascular age-related macular degeneration.

Authors:  Eleonora M Lad; Scott W Cousins; John S Van Arnam; Alan D Proia
Journal:  Graefes Arch Clin Exp Ophthalmol       Date:  2015-07-07       Impact factor: 3.117

4.  Flow cytometric identification of a minority population of MHC class II positive cells in the normal rat retina distinct from CD45lowCD11b/c+CD4low parenchymal microglia.

Authors:  A D Dick; A L Ford; J V Forrester; J D Sedgwick
Journal:  Br J Ophthalmol       Date:  1995-09       Impact factor: 4.638

5.  Mean retinal ganglion cell axon diameter varies with location in the human retina.

Authors:  T FitzGibbon; S F Taylor
Journal:  Jpn J Ophthalmol       Date:  2012-09-27       Impact factor: 2.447

6.  Innate Immunity in Age-Related Macular Degeneration.

Authors:  Yikui Zhang; Wai T Wong
Journal:  Adv Exp Med Biol       Date:  2021       Impact factor: 2.622

Review 7.  Role of microglia adenosine A(2A) receptors in retinal and brain neurodegenerative diseases.

Authors:  Ana R Santiago; Filipa I Baptista; Paulo F Santos; Gonçalo Cristóvão; António F Ambrósio; Rodrigo A Cunha; Catarina A Gomes
Journal:  Mediators Inflamm       Date:  2014-07-16       Impact factor: 4.711

8.  The avascular zone and neuronal remodeling of the fovea in Parkinson disease.

Authors:  Shahnaz Miri; Eric M Shrier; Sofya Glazman; Yin Ding; Ivan Selesnick; Piotr B Kozlowski; Ivan Bodis-Wollner
Journal:  Ann Clin Transl Neurol       Date:  2015-01-08       Impact factor: 4.511

9.  Phenotypes, distribution, and morphological features of antigen-presenting cells in the murine cornea following intravitreal injection.

Authors:  Qianli Meng; Peizeng Yang; Haoli Jin; James T Rosenbaum; Bing Li; Haining Zhang; Hongyan Zhou; Xiangkun Huang; Stephen R Planck
Journal:  Mol Vis       Date:  2007-03-28       Impact factor: 2.367
  9 in total

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