| Literature DB >> 1751031 |
A Clow1, T Hussain, V Glover, M Sandler, D T Dexter, M Walker.
Abstract
(-)-Deprenyl (0.25 or 2 mg/kg) or saline was injected daily into male Wistar rats for 3 weeks. The striata were dissected out and soluble and particulate superoxide dismutase activity measured. (-)-Deprenyl at 2 mg/kg induced a significant increase in the soluble but not the particulate form of the enzyme. The possibility that this action contributes to the ability of (-)-deprenyl to retard nigral degeneration in man and prolong life in rats is discussed.Entities:
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Year: 1991 PMID： 1751031 DOI： 10.1007/bf01250378
Source DB: PubMed Journal: J Neural Transm Gen Sect