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Literature DB >> 1751025

A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure.

Abstract

Guinea pig cerebrocortical synaptosome preparations were used to study the effect of compression to 62 ATA on 45Ca2+ uptake and [3H]GABA release using a calcium ionophore A 23187, which bypasses the voltage-sensitive calcium channel. Pressure was found to exert a suppressive effect on the A 23187-induced release of [3H]GABA, while having no significant effect on A 23187-stimulated 45Ca2+ uptake. On the other hand, both depolarization-induced 45Ca2+ uptake and [3H]GABA release were inhibited by pressure exposure. These results suggest that pressure may suppress GABA release by affecting pre-synaptic events subsequent to calcium influx.

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Year: 1991 PMID： 1751025 DOI： 10.1007/bf01250371

Source DB: PubMed Journal: J Neural Transm Gen Sect

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References

19 in total

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A 23187-stimulated calcium uptake and GABA release by cerebrocortical synaptosomes: effects of high pressure.

1. Release of dopamine from striatal synaptosomes: high pressure effects.

2. Protein determination in membrane and lipoprotein samples: manual and automated procedures.

3. A simple apparatus for studying the release of neurotransmitters from synaptosomes.

4. Modulation of gamma-aminobutyric acid transport in nerve endings: role of extracellular gamma-aminobutyric acid and of cationic fluxes.

5. Release of gamma-aminobutyric acid from isolated brain synaptosomes during semicarbazide-induced convulsions.

6. Effects of high pressure on the release of excitatory amino acids by brain synaptosomes.

7. Effect of pressure on [3H]GABA release by synaptosomes isolated from cerebral cortex.

8. Effect of pressure on the release of radioactive glycine and gamma-aminobutyric acid from spinal cord synaptosomes.

9. Antagonism by taurine of pressure-induced tremor in the guinea pig.

10. Calcium transport by intact synaptosomes. Influence of ionophore A23187 on plasma-membrane potential, plasma-membrane calcium transport, mitochondrial membrane potential, respiration, cytosolic free-calcium concentration and noradrenaline release.