| Literature DB >> 17509567 |
Agnieszka A Ardelt1, Naseem Anjum, Kiran F Rajneesh, Piotr Kulesza, Raymond C Koehler.
Abstract
Peri-infarct increase of vascular density has been observed in animals and in humans with ischemic stroke. Increased peri-infarct vascular density correlates with improved functional outcome after stroke. We hypothesized that pre-treatment with estradiol will increase post-ischemic peri-infarct capillary density in a rat model of transient ischemic stroke. Estradiol, compared to placebo, augmented post-ischemic peri-infarct vascular density by 22% 10 days after stroke. Recovery of forelimb function was not improved with estradiol treatment on day three and nine post-stroke. Loss of estradiol may limit repair in the peri-infarct region by limiting angiogenesis, but functional significance in stroke recovery requires further investigation.Entities:
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Year: 2007 PMID： 17509567 PMCID： PMC2045124 DOI： 10.1016/j.expneurol.2007.04.002
Source DB: PubMed Journal: Exp Neurol ISSN： 0014-4886 Impact factor: 5.330