OBJECTIVE: to explore muscle mitochondria function with respect to age, functional status and nutrition in community-living and recovering hospitalized older subjects. MEASUREMENTS: subjects were assessed for nutrition, hand-grip strength, 10-meter gait time, a modified timed get-up-and-go test and activities of daily living score (ADL). 31P magnetic resonance spectroscopy (31P MRS) was used to assess the initial rate of post-exercise phosphocreatine recovery (ViPCr) for mitochondrial function evaluation in 25 hospitalized older subjects (86.1 + 5.3 y) and in 25 community-living younger ones (74.5 + 6.2 y). RESULTS: in multiple linear regression, longer time on the get-up-and-go test was independently associated with lower values of ViPCr (p = 0.008). For all subjects and in the 8 patients unable to perform this test, ViPCr was negatively correlated with the ADL score (respectively p < 0.001 and p = 0.025). CONCLUSION: particularly in hospitalized and frail older subjects, muscle mitochondrial function was related to the global physical functional assessment.
OBJECTIVE: to explore muscle mitochondria function with respect to age, functional status and nutrition in community-living and recovering hospitalized older subjects. MEASUREMENTS: subjects were assessed for nutrition, hand-grip strength, 10-meter gait time, a modified timed get-up-and-go test and activities of daily living score (ADL). 31P magnetic resonance spectroscopy (31P MRS) was used to assess the initial rate of post-exercise phosphocreatine recovery (ViPCr) for mitochondrial function evaluation in 25 hospitalized older subjects (86.1 + 5.3 y) and in 25 community-living younger ones (74.5 + 6.2 y). RESULTS: in multiple linear regression, longer time on the get-up-and-go test was independently associated with lower values of ViPCr (p = 0.008). For all subjects and in the 8 patients unable to perform this test, ViPCr was negatively correlated with the ADL score (respectively p < 0.001 and p = 0.025). CONCLUSION: particularly in hospitalized and frail older subjects, muscle mitochondrial function was related to the global physical functional assessment.
Authors: Adam J Santanasto; Paul M Coen; Nancy W Glynn; Kevin E Conley; Sharon A Jubrias; Francesca Amati; Elsa S Strotmeyer; Robert M Boudreau; Bret H Goodpaster; Anne B Newman Journal: Exp Gerontol Date: 2016-04-12 Impact factor: 4.032
Authors: Mary C Masters; Jingyan Yang; Jordan E Lake; Alison G Abraham; Lawrence Kingsley; Todd T Brown; Frank J Palella; Kristine M Erlandson Journal: AIDS Date: 2022-04-01 Impact factor: 4.632
Authors: Ariel C Zane; David A Reiter; Michelle Shardell; Donnie Cameron; Eleanor M Simonsick; Kenneth W Fishbein; Stephanie A Studenski; Richard G Spencer; Luigi Ferrucci Journal: Aging Cell Date: 2017-02-09 Impact factor: 9.304