Literature DB >> 17502403

Inhibition of type III secretion in Salmonella enterica serovar Typhimurium by small-molecule inhibitors.

Debra L Hudson1, Abigail N Layton, Terry R Field, Alison J Bowen, Hans Wolf-Watz, Mikael Elofsson, Mark P Stevens, Edouard E Galyov.   

Abstract

Type III secretion systems (T3SS) are conserved in many pathogenic gram-negative bacteria. Small molecules that specifically target T3SS in Yersinia and Chlamydia spp. have recently been identified. Here we show that two such compounds inhibit Salmonella T3SS-1, preventing secretion of T3SS-1 effectors, invasion of cultured epithelial cells, and enteritis in vivo.

Entities:  

Mesh：

Substances：

Year:  2007        PMID： 17502403      PMCID： PMC1913257          DOI： 10.1128/AAC.01492-06

Source DB:  PubMed          Journal:  Antimicrob Agents Chemother        ISSN： 0066-4804            Impact factor:   5.191


  23 in total

Review 1.  Molecular basis of Salmonella-induced enteritis.

Authors:  T S Wallis; E E Galyov
Journal:  Mol Microbiol       Date:  2000-06       Impact factor: 3.501

2.  Identification of SopE2 from Salmonella typhimurium, a conserved guanine nucleotide exchange factor for Cdc42 of the host cell.

Authors:  S Stender; A Friebel; S Linder; M Rohde; S Mirold; W D Hardt
Journal:  Mol Microbiol       Date:  2000-06       Impact factor: 3.501

3.  A small-molecule inhibitor of type III secretion inhibits different stages of the infectious cycle of Chlamydia trachomatis.

Authors:  Sandra Muschiol; Leslie Bailey; Asa Gylfe; Charlotta Sundin; Kjell Hultenby; Sven Bergström; Mikael Elofsson; Hans Wolf-Watz; Staffan Normark; Birgitta Henriques-Normark
Journal:  Proc Natl Acad Sci U S A       Date:  2006-09-14       Impact factor: 11.205

4.  Small-molecule inhibitors specifically targeting type III secretion.

Authors:  R Nordfelth; A M Kauppi; H A Norberg; H Wolf-Watz; M Elofsson
Journal:  Infect Immun       Date:  2005-05       Impact factor: 3.441

5.  Transcriptional inhibitor of virulence factors in enteropathogenic Escherichia coli.

Authors:  Annick Gauthier; Marilyn L Robertson; Michael Lowden; J Antonio Ibarra; José Luis Puente; B Brett Finlay
Journal:  Antimicrob Agents Chemother       Date:  2005-10       Impact factor: 5.191

Review 6.  The functional interface between Salmonella and its host cell: opportunities for therapeutic intervention.

Authors:  Jayesh C Patel; Olivia W Rossanese; Jorge E Galán
Journal:  Trends Pharmacol Sci       Date:  2005-09-22       Impact factor: 14.819

7.  Treatment of Chlamydia trachomatis with a small molecule inhibitor of the Yersinia type III secretion system disrupts progression of the chlamydial developmental cycle.

Authors:  K Wolf; H J Betts; B Chellas-Géry; S Hower; C N Linton; K A Fields
Journal:  Mol Microbiol       Date:  2006-09       Impact factor: 3.501

8.  Cytotoxicity of salicylaldehyde benzoylhydrazone analogs and their transition metal complexes: quantitative structure-activity relationships.

Authors:  E W Ainscough; A M Brodie; W A Denny; G J Finlay; S A Gothe; J D Ranford
Journal:  J Inorg Biochem       Date:  1999 Nov-Dec       Impact factor: 4.155

9.  Secreted effector proteins of Salmonella dublin act in concert to induce enteritis.

Authors:  M A Jones; M W Wood; P B Mullan; P R Watson; T S Wallis; E E Galyov
Journal:  Infect Immun       Date:  1998-12       Impact factor: 3.441

10.  Identification of host-specific colonization factors of Salmonella enterica serovar Typhimurium.

Authors:  Eirwen Morgan; June D Campbell; Sonya C Rowe; Jennie Bispham; Mark P Stevens; Alison J Bowen; Paul A Barrow; Duncan J Maskell; Timothy S Wallis
Journal:  Mol Microbiol       Date:  2004-11       Impact factor: 3.501
View more
  49 in total

1.  Derivatives of plant phenolic compound affect the type III secretion system of Pseudomonas aeruginosa via a GacS-GacA two-component signal transduction system.

Authors:  Akihiro Yamazaki; Jin Li; Quan Zeng; Devanshi Khokhani; William C Hutchins; Angela C Yost; Eulandria Biddle; Eric J Toone; Xin Chen; Ching-Hong Yang
Journal:  Antimicrob Agents Chemother       Date:  2011-10-03       Impact factor: 5.191

Review 2.  Computational prediction of type III and IV secreted effectors in gram-negative bacteria.

Authors:  Jason E McDermott; Abigail Corrigan; Elena Peterson; Christopher Oehmen; George Niemann; Eric D Cambronne; Danna Sharp; Joshua N Adkins; Ram Samudrala; Fred Heffron
Journal:  Infect Immun       Date:  2010-10-25       Impact factor: 3.441

3.  Visible fluorescence detection of type III protein secretion from bacterial pathogens.

Authors:  Jacob S Yount; Lun K Tsou; Paul D Dossa; Amy L Kullas; Adrianus W M van der Velden; Howard C Hang
Journal:  J Am Chem Soc       Date:  2010-06-23       Impact factor: 15.419

4.  Discovery and characterization of inhibitors of Pseudomonas aeruginosa type III secretion.

Authors:  Daniel Aiello; John D Williams; Helena Majgier-Baranowska; Ishan Patel; Norton P Peet; Jin Huang; Stephen Lory; Terry L Bowlin; Donald T Moir
Journal:  Antimicrob Agents Chemother       Date:  2010-02-22       Impact factor: 5.191

5.  Characterization of the effects of salicylidene acylhydrazide compounds on type III secretion in Escherichia coli O157:H7.

Authors:  Jai J Tree; Dai Wang; Carol McInally; Arvind Mahajan; Abigail Layton; Irene Houghton; Mikael Elofsson; Mark P Stevens; David L Gally; Andrew J Roe
Journal:  Infect Immun       Date:  2009-07-27       Impact factor: 3.441

6.  Quantification of real-time Salmonella effector type III secretion kinetics reveals differential secretion rates for SopE2 and SptP.

Authors:  Schuyler B Van Engelenburg; Amy E Palmer
Journal:  Chem Biol       Date:  2008-06

7.  Norepinephrine augments Salmonella enterica-induced enteritis in a manner associated with increased net replication but independent of the putative adrenergic sensor kinases QseC and QseE.

Authors:  Gillian D Pullinger; Sonya C Carnell; Fathima F Sharaff; Pauline M van Diemen; Francis Dziva; Eirwen Morgan; Mark Lyte; Primrose P E Freestone; Mark P Stevens
Journal:  Infect Immun       Date:  2009-11-02       Impact factor: 3.441

Review 8.  Chemical inhibitors of the type three secretion system: disarming bacterial pathogens.

Authors:  Miles C Duncan; Roger G Linington; Victoria Auerbuch
Journal:  Antimicrob Agents Chemother       Date:  2012-07-30       Impact factor: 5.191

9.  Cytosporone B, an inhibitor of the type III secretion system of Salmonella enterica serovar Typhimurium.

Authors:  Jianfang Li; Chao Lv; Weiyang Sun; Zhenyu Li; Xiaowei Han; Yaoyao Li; Yuemao Shen
Journal:  Antimicrob Agents Chemother       Date:  2013-03-04       Impact factor: 5.191

Review 10.  Promises and Challenges of the Type Three Secretion System Injectisome as an Antivirulence Target.

Authors:  Alyssa C Fasciano; Lamyaa Shaban; Joan Mecsas
Journal:  EcoSal Plus       Date:  2019-02
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.