| Literature DB >> 17502136 |
Richard Sulsky1, David R Magnin, Yanting Huang, Ligaya Simpkins, Prakash Taunk, Manorama Patel, Yeheng Zhu, Terry R Stouch, Donna Bassolino-Klimas, Rex Parker, Thomas Harrity, Robert Stoffel, David S Taylor, Thomas B Lavoie, Kevin Kish, Bruce L Jacobson, Steven Sheriff, Leonard P Adam, William R Ewing, Jeffrey A Robl.
Abstract
Herein we report the first disclosure of biphenyl azoles that are nanomolar binders of adipocyte fatty acid binding protein (aFABP or aP2) with up to thousand-fold selectivity against muscle fatty acid binding protein and epidermal fatty acid binding protein. In addition a new radio-ligand to determine binding against the three fatty acid binding proteins was also synthesized.Entities:
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Year: 2006 PMID： 17502136 DOI： 10.1016/j.bmcl.2006.12.044
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823