AIM: To evaluate the effects of cytokines, biochemical parameters and demographic features on clinical outcomes of acute renal failure (ARF). PATIENTS AND METHODS: 59 patients with acute renal failure (28 men, 31 women) were enrolled to the study. Cytokines, biochemical parameters, and complete blood count were measured. Patients were divided into two groups: as survivors (group 1, n = 46) and nonsurvivors (group 2, n = 13). RESULTS: Mean age of patients were 52.3 +/- 17.9 years. 46 patients survived (77.9%) and 13 patients died (22.1%). There was a statistically significant relationship between IL-2R, IL-6, and TNF-alpha levels and mortality rates (p = 0.004, p = 0.016, p = 0.020, respectively) and between TC levels and mortality rates (p = 0.041). In multivariable logistic regression analysis, the effects of proinflammatory cytokines (IL-1beta, IL-2R, IL-6, TNFalpha, CRP, and ESR) on the clinical outcomes in ARF was observed to be statistically significant (r = 0.341, p = 0.005). CONCLUSION: We realized that in totally demographic features (male gender, advanced age, poor nutritional status), biochemical parameters (TC, albumin, and hemoglobin) and cytokine levels (IL-2R, IL-6, TNF-alpha), CRP and ESR may be predictive factors for mortality in patients with ARF.
AIM: To evaluate the effects of cytokines, biochemical parameters and demographic features on clinical outcomes of acute renal failure (ARF). PATIENTS AND METHODS: 59 patients with acute renal failure (28 men, 31 women) were enrolled to the study. Cytokines, biochemical parameters, and complete blood count were measured. Patients were divided into two groups: as survivors (group 1, n = 46) and nonsurvivors (group 2, n = 13). RESULTS: Mean age of patients were 52.3 +/- 17.9 years. 46 patients survived (77.9%) and 13 patients died (22.1%). There was a statistically significant relationship between IL-2R, IL-6, and TNF-alpha levels and mortality rates (p = 0.004, p = 0.016, p = 0.020, respectively) and between TC levels and mortality rates (p = 0.041). In multivariable logistic regression analysis, the effects of proinflammatory cytokines (IL-1beta, IL-2R, IL-6, TNFalpha, CRP, and ESR) on the clinical outcomes in ARF was observed to be statistically significant (r = 0.341, p = 0.005). CONCLUSION: We realized that in totally demographic features (male gender, advanced age, poor nutritional status), biochemical parameters (TC, albumin, and hemoglobin) and cytokine levels (IL-2R, IL-6, TNF-alpha), CRP and ESR may be predictive factors for mortality in patients with ARF.
Authors: Paweena Susantitaphong; Mary C Perianayagam; Hocine Tighiouart; Orfeas Liangos; Joseph V Bonventre; Bertrand L Jaber Journal: Nephron Clin Pract Date: 2013-06-21
Authors: Tuula K Outinen; Satu M Mäkelä; Ilpo O Ala-Houhala; Heini Sa Huhtala; Mikko Hurme; Antti S Paakkala; Ilkka H Pörsti; Jaana T Syrjänen; Jukka T Mustonen Journal: BMC Infect Dis Date: 2010-05-25 Impact factor: 3.090
Authors: Kada Klouche; Laurent Amigues; Marion Morena; Vincent Brunot; Anne Marie Dupuy; Audrey Jaussent; Marie Christine Picot; Noémie Besnard; Delphine Daubin; Jean Paul Cristol Journal: BMC Nephrol Date: 2017-12-22 Impact factor: 2.388